In normal prostate, neuroendocrine (NE) cells are rare and interspersed among the
epithelium. These cells are believed to provide trophic signals to epithelial cell populations …

Molecular biomarkers hold promise to advance the noninvasive diagnosis of male
reproductive system disorders and facilitate the identification and management of these …

Transcript fusions as a result of chromosomal rearrangements have been a focus of
attention in cancer as they provide attractive therapeutic targets. To identify novel fusion …

Standardized and reproducible preclinical models that recapitulate the dynamics of prostate
cancer are urgently needed. We established a bank of transplantable patient-derived …

The current paradigm of cancer care relies on predictive nomograms which integrate
detailed histopathology with clinical data. However, when predictions fail, the consequences …

Although gene fusions have been recognized as important drivers of cancer for decades,
our understanding of the prevalence and function of gene fusions has been revolutionized …

Prostate cancer (PCa) is the most commonly diagnosed noncutaneous malignancy and
second leading cause of cancer-related deaths in US males. Clinically, locally confined …

Purpose: Enzalutamide (ENZ) is a potent androgen receptor (AR) antagonist with activity in
castration-resistant prostate cancer (CRPC); however, progression to ENZ-resistant (ENZ-R) …

Neuroendocrine (NE) differentiation in tumors of the prostate or in the setting of prostate
cancer (PCa) is rare. A survey of these lesions is presented, including usual PCa with focal …

Do cancer cells escape the confinement of their original habitat in the primary tumor or are
they forced out by ecologic changes in their home niche? Describing metastasis in terms of …