Therapeutic and toxic blood concentrations of nearly 1,000 drugs and other xenobiotics
M Schulz, S Iwersen-Bergmann, H Andresen… - Critical care, 2012 - Springer
Introduction In order to assess the significance of drug levels measured in intensive care
medicine, clinical and forensic toxicology, as well as for therapeutic drug monitoring, it is …
medicine, clinical and forensic toxicology, as well as for therapeutic drug monitoring, it is …
Nano-sized magnetic core-shell and bulk molecularly imprinted polymers for selective extraction of amiodarone from human plasma
Bulk and magnetic core-shell Molecularly Imprinted Polymers (MMIPs) have been
introduced and compared to extract and determine amiodarone from a complex matrix, ie …
introduced and compared to extract and determine amiodarone from a complex matrix, ie …
5% lidocaine medicated plaster for the treatment of postherpetic neuralgia: a review of the clinical safety and tolerability
ML Navez, C Monella, I Bösl, D Sommer, C Delorme - Pain and therapy, 2015 - Springer
Postherpetic neuralgia (PHN) is a common, very painful, and often long-lasting complication
of herpes zoster which is frequently underdiagnosed and undertreated. It mainly affects the …
of herpes zoster which is frequently underdiagnosed and undertreated. It mainly affects the …
Simultaneous determination of 6 beta-blockers, 3 calcium-channel antagonists, 4 angiotensin-II antagonists and 1 antiarrhytmic drug in post-mortem whole blood by …
L Kristoffersen, EL Øiestad, MS Opdal, M Krogh… - … of Chromatography B, 2007 - Elsevier
A method for the simultaneous determination of the beta-blockers atenolol, sotalol,
metoprolol, bisoprolol, propranolol and carvedilol, the calcium-channel antagonists …
metoprolol, bisoprolol, propranolol and carvedilol, the calcium-channel antagonists …
Direct analysis in real time-mass spectrometry for rapid quantification of five anti-arrhythmic drugs in human serum: application to therapeutic drug monitoring
Y Gui, Y Lu, S Li, M Zhang, X Duan, CC Liu, J Jia… - Scientific reports, 2020 - nature.com
Therapeutic drug monitoring (TDM) is necessary for the optimal administration of anti-
arrhythmic drugs in the treatment of heart arrhythmia. The present study aimed to develop …
arrhythmic drugs in the treatment of heart arrhythmia. The present study aimed to develop …
New use for an old drug: quinidine in KCNT1-related epilepsy therapy
R Liu, L Sun, Y Wang, Q Wang, J Wu - Neurological Sciences, 2023 - Springer
KCNT1 has been known to encode a subunit of the tetrameric sodium activated potassium
channel (KNa1. 1). Pathogenic variants of KCNT1, especially gain-of-function (GOF) …
channel (KNa1. 1). Pathogenic variants of KCNT1, especially gain-of-function (GOF) …
Preclinical Torsades-de-Pointes screens: advantages and limitations of surrogate and direct approaches in evaluating proarrhythmic risk
GA Gintant - Pharmacology & therapeutics, 2008 - Elsevier
The successful development of novel drugs requires the ability to detect (and avoid)
compounds that may provoke Torsades-de-Pointes (TdeP) arrhythmia while endorsing …
compounds that may provoke Torsades-de-Pointes (TdeP) arrhythmia while endorsing …
Analysis of stochastic fluctuations in responsiveness is a critical step toward personalized anesthesia
Traditionally, drug dosing is based on a concentration-response relationship estimated in a
population. Yet, in specific individuals, decisions based on the population-level effects …
population. Yet, in specific individuals, decisions based on the population-level effects …
Safety and efficacy outcomes of long-term treatment up to 4 years with 5% lidocaine medicated plaster in patients with post-herpetic neuralgia
R Sabatowski, G Hans, I Tacken… - Current Medical …, 2012 - Taylor & Francis
Objective: Prospective evaluation of the long-term efficacy and safety of the 5% lidocaine
medicated plaster in patients with post-herpetic neuralgia (PHN). Research design and …
medicated plaster in patients with post-herpetic neuralgia (PHN). Research design and …
Towards point of care systems for the therapeutic drug monitoring of imatinib
CM Pearce, M Resmini - Analytical and Bioanalytical Chemistry, 2020 - Springer
Therapeutic drug monitoring is used in the clinical setting in the optimisation of dosages to
overcome inter-patient pharmacokinetic variability, increasing efficacy whilst reducing …
overcome inter-patient pharmacokinetic variability, increasing efficacy whilst reducing …