Introduction Benznidazole, the drug of choice for treating Chagas Disease (CD), has
significant limitations, such as poor cure efficacy, mainly in the chronic phase of CD …

African Animal Trypanosomiasis (AAT), caused predominantly by Trypanosoma brucei
brucei, T. vivax and T. congolense, is a fatal livestock disease throughout Sub-Saharan …

Chagas disease is a tropical neglected disease that affects millions of people worldwide, still
demanding a more effective and safer therapy, especially in its chronic phase which lacks a …

Chagas disease (CD) caused by the protozoan Trypanosoma cruzi affects more than six
million people worldwide. Treatment is restricted to benznidazole (Bz) and nifurtimox (Nf) …

Toxoplasmosis is a common protozoan infection that can have severe outcomes in the
immunocompromised and during pregnancy, but treatment options are limited. Recently …

Chagas disease, a silent but widespread disease that mainly affects a socioeconomically
vulnerable population, lacks innovative safe drug therapy. The available drugs …

New affordable drugs are needed for the treatment of infection with the protozoan parasite
Trypanosoma cruzi responsible for the Chagas disease (CD). Only two old drugs are …

Trypanosoma cruzi is a protozoan parasite and the etiological agent of Chagas disease, a
debilitating and sometimes fatal disease that continues to spread to new areas. Yet, Chagas …

Among the scarce validated drug targets against Chagas disease (CD), caused by
Trypanosoma cruzi, the parasite's nucleoside salvage system has recently attracted …

Simple Summary Chagas disease, caused by the protozoan Trypanosoma cruzi, is a
neglected tropical disease that affects 6–7 million people worldwide. It is a global disease …