Extensive research into ankylosing spondylitis (AS) has suggested the major role of
genetics, immune reactions, and the joint–gut axis in its etiology, although an ultimate …

Axial spondyloarthritis is a prevalent form of chronic arthritis which is related to psoriatic
arthritis and skin psoriasis. TNF and IL-17A as well as IL-17F are key cytokines contributing …

Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by inflammatory
back pain and spinal ankylosis due to pathological new bone formation. Here, we identified …

Objective The aim of this study was to identify the role of Piezo1-mediated
mechanotransduction in entheseal pathological new bone formation and to explore the …

B-cells have received little attention in axial spondyloarthritis (axSpA) and for this reason
their role in pathogenesis remains unclear. However, there are indications that B-cells may …

The tumor necrosis factor (TNF) and IL-23/IL-17 axes are the main therapeutic targets in
spondyloarthritis. Despite the clinical efficacy of blocking either pathway, monotherapy does …

Subclinical inflammation is associated with Spondylarthritis (SpA). SpA patients show
features of dysbiosis, altered gut barrier function, and local expansion of innate and innate …

Ankylosing spondylitis (AS) is an autoinflammatory disease that manifests with the unique
feature of enthesitis. Gut microbiota, HLA-B* 27, and biomechanical stress mutually …

Understanding the complex mechanisms underlying a disorder such as spondyloarthritis
(SpA) may benefit from studying animal models. Several suitable models have been …

Spondyloarthritis (SpA) is a spectrum of chronic inflammatory joint diseases that frequently
presents with inflammation of the axial skeleton, peripheral joints, entheses, skin, and gut …