Discovering the structure and dynamics of transcriptional regulatory events in the genome
with cellular and temporal resolution is crucial to understanding the regulatory …

Epigenetic alterations, a well-recognized cancer hallmark, are driven by chromatin
regulators (CRs). However, little is known about the extent of CR deregulation in cancer, and …

Genomic regions with gene regulatory enhancer activity turnover rapidly across mammals.
In contrast, gene expression patterns and transcription factor binding preferences are largely …

An essential step for understanding the transcriptional circuits that control development and
physiology is the global identification and characterization of regulatory elements. Here, we …

Animal species present relatively high levels of gene conservation, and yet they display a
great variety of cell type and tissue phenotypes. These diverse phenotypes are mainly …

The transition from proliferating precursor cells to post-mitotic differentiated cells is crucial for
development, tissue homeostasis, and tumor suppression. To study cell-cycle exit during …

Genetic incompatibilities are an important component of reproductive isolation. Although
theoretical studies have addressed their evolution, little is known about their maintenance …

Alternative splicing is regulated by RNA binding proteins (RBPs) that recognize pre-mRNA
sequence elements and activate or repress adjacent exons. Here, we used RNA …

Caenorhabditis elegans is a powerful model for studying gene regulation, as it has a
compact genome and a wealth of genomic tools. However, identification of regulatory …

Transcription factor (TF) networks are a key determinant of cell fate decisions in mammalian
development and adult tissue homeostasis and are frequently corrupted in disease …