The sonic hedgehog (Shh) signaling pathway is a major regulator of cell differentiation, cell
proliferation, and tissue polarity. Aberrant activation of the Shh pathway has been shown in …

Oligodendrocyte precursor cells (OPCs) originate in the ventricular zones (VZs) of the brain
and spinal cord and migrate throughout the developing central nervous system (CNS) …

The hedgehog (HH) pathway is well known for its mitogenic and morphogenic functions
during development, and HH signaling continues in discrete populations of cells within …

Gli zinc-finger proteins are transcription factors involved in the intracellular signal
transduction controlled by the Hedgehog family of secreted molecules. They are frequently …

Abstract The Hedgehog (Hh) pathway has been implicated in a wide variety of human
tumors, and early clinical trials with pathway antagonists have validated Hh signaling as a …

The current view is that breast cancer is a stem cell disease characterized by the existence
of cancer cells with stem-like features and tumor-initiating potential. These cells are made …

Glioblastoma (GBM) is the most malignant brain tumor and accounts for most adult brain
tumors. Current available treatment options for GBM are multimodal, which include surgical …

A cohort of genes associated with embryonic stem (ES) cell behaviour, including NANOG,
are expressed in a number of human cancers. They form an ES‐like signature we first …

BACKGROUND & AIMS: The pathogenesis of cirrhosis, a disabling outcome of defective
liver repair, involves deregulated accumulation of myofibroblasts derived from quiescent …

An essential role for Hedgehog (Hh) signaling in human cancer has been established
beyond doubt. At present, targeting Hh signaling has mainly been investigated with SMO …