Addiction to alcohol and drugs is a major social and economic problem, and there is
considerable interest in understanding the molecular mechanisms that promote addictive …

Tobacco smoking continues to be a major global health hazard despite significant public
awareness of its harmful consequences. Although several treatment options are currently …

Historically, neuroscientific research into addiction has emphasized affective and
reinforcement mechanisms as the essential elements underlying the pursuit of drugs, their …

Introduction: Current FDA-approved smoking cessation pharmacotherapies have limited
efficacy and are associated with high rates of relapse. Therefore, there is a clear need to …

Rationale Treatments based on exposure/response prevention (Exp/RP) produce only
modest benefits in substance dependence disorders. However, a new strategy, which has …

Contributions of brain glutamate (Glu) to conscious emotion are not well understood. Here,
we evaluate the relationship of experimentally induced change in neocortical Glu (ΔGlu) and …

Rationale Varenicline, a partial agonist at α4β2 nicotinic receptors (nAChRs) aids smoking
cessation by reducing craving. Successful quitting may be associated with greater inhibitory …

The world population is growing older and age-related cognitive decline is becoming a
burden of societal importance. D-serine is an endogenous amino acid that activates the co …

The glutamatergic neurotransmission system and the N-methyl-D-aspartate receptor
(NMDAR) have been implicated in smoking and alcohol consumption behavior. Preclinical …

Contributions of brain glutamate to conscious emotion are not well understood. Here we
evaluate the relationship of experimentally-induced change in neocortical glutamate (ΔGlu) …