Pathogenesis of endometriosis: New insights into prospective therapies

R Kapoor, CA Stratopoulou, MM Dolmans - International journal of …, 2021 - mdpi.com
Endometriosis is a female reproductive disorder characterized by growth of uterine cells and
tissue in distant sites. Around 2–10% of women experience this condition during …

Peritoneal immune microenvironment of endometriosis: Role and therapeutic perspectives

S Chen, Y Liu, Z Zhong, C Wei, Y Liu… - Frontiers in Immunology, 2023 - frontiersin.org
Endometriosis, an estrogen-dependent chronic inflammatory disease characterized by the
growth of endometrium-like tissues outside the uterine cavity, affects 10% of reproductive …

The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions

N Rahmioglu, S Mortlock, M Ghiasi, PL Møller… - Nature …, 2023 - nature.com
Endometriosis is a common condition associated with debilitating pelvic pain and infertility.
A genome-wide association study meta-analysis, including 60,674 cases and 701,926 …

Progesterone as an anti-inflammatory drug and immunomodulator: new aspects in hormonal regulation of the inflammation

TA Fedotcheva, NI Fedotcheva, NL Shimanovsky - Biomolecules, 2022 - mdpi.com
The specific regulation of inflammatory processes by steroid hormones has been actively
studied in recent years, especially by progesterone (P4) and progestins. The mechanisms of …

Endometriosis: a disease with few direct treatment options

PRC França, ACP Lontra, PD Fernandes - Molecules, 2022 - mdpi.com
Endometriosis is a gynecological condition characterized by the growth of endometrium-like
tissues inside and outside the pelvic cavity. The evolution of the disease can lead to infertility …

Epigenetic regulation and T-cell responses in endometriosis–something other than autoimmunity

D Szukiewicz - Frontiers in immunology, 2022 - frontiersin.org
Endometriosis is defined as the presence of endometrial-like glands and stroma located
outside the uterine cavity. This common, estrogen dependent, inflammatory condition affects …

Epigenetic dysregulation in endometriosis: implications for pathophysiology and therapeutics

RM Marquardt, DN Tran, BA Lessey… - Endocrine …, 2023 - academic.oup.com
Endometriosis is a prevalent gynecological condition associated with pelvic pain and
infertility. Despite more than a century of research, the etiology of endometriosis still eludes …

Role of inflammation in benign gynecologic disorders: from pathogenesis to novel therapies

A AlAshqar, L Reschke, GW Kirschen… - Biology of …, 2021 - academic.oup.com
Emerging evidence supports the notion that inflammation fosters the development of
common benign gynecologic disorders, including uterine leiomyoma, endometriosis, and …

Endometriosis and polycystic ovary syndrome are diametric disorders

NL Dinsdale, BJ Crespi - Evolutionary applications, 2021 - Wiley Online Library
Evolutionary and comparative approaches can yield novel insights into human adaptation
and disease. Endometriosis and polycystic ovary syndrome (PCOS) each affect up to 10% of …

The complex roles of adipokines in polycystic ovary syndrome and endometriosis

S Schüler-Toprak, O Ortmann, C Buechler, O Treeck - Biomedicines, 2022 - mdpi.com
Polycystic ovary syndrome (PCOS) and endometriosis are frequent diseases of the female
reproductive tract causing high morbidity as they can significantly affect fertility and quality of …