Role of reactive oxygen species in cancer progression: molecular mechanisms and recent advancements

V Aggarwal, HS Tuli, A Varol, F Thakral, MB Yerer… - Biomolecules, 2019 - mdpi.com
Reactive oxygen species (ROS) play a pivotal role in biological processes and continuous
ROS production in normal cells is controlled by the appropriate regulation between the silver …

Human papillomavirus E6 and E7: the cervical cancer hallmarks and targets for therapy

A Pal, R Kundu - Frontiers in microbiology, 2020 - frontiersin.org
Human papillomavirus (HPV)-induced cervical cancer is a major health issue among
women from the poorly/under-developed sectors of the world. It accounts for a high-mortality …

Reactive oxygen species (ROS) and cancer: Role of antioxidative nutraceuticals

S Prasad, SC Gupta, AK Tyagi - Cancer letters, 2017 - Elsevier
Extensive research over the past half a century indicates that reactive oxygen species (ROS)
play an important role in cancer. Although low levels of ROS can be beneficial, excessive …

The not-so-good, the bad and the ugly: HPV E5, E6 and E7 oncoproteins in the orchestration of carcinogenesis

O Basukala, L Banks - Viruses, 2021 - mdpi.com
Infection with HPV starts with the access of the viral particles to basal cells in the epidermis,
potentially via microtraumas to the skin. The basal cells are able to keep away these …

Single-cell transcriptomics reveals the landscape of intra-tumoral heterogeneity and stemness-related subpopulations in liver cancer

DWH Ho, YM Tsui, KMF Sze, LK Chan, TT Cheung… - Cancer letters, 2019 - Elsevier
Hepatocellular carcinoma (HCC) is heterogeneous, rendering its current curative treatments
ineffective. The emergence of single-cell genomics represents a powerful strategy in …

Reactive oxygen species as intracellular signaling molecules in the cardiovascular system

AV Krylatov, LN Maslov, NS Voronkov… - Current cardiology …, 2018 - ingentaconnect.com
Background: Redox signaling plays an important role in the lives of cells. This signaling not
only becomes apparent in pathologies but is also thought to be involved in maintaining …

BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity

RD Rasmussen, MK Gajjar, L Tuckova… - Nature …, 2016 - nature.com
Oncogene-evoked replication stress (RS) fuels genomic instability in diverse cancer types.
Here we report that BRCA1, traditionally regarded a tumour suppressor, plays an …

miR-92a is upregulated in cervical cancer and promotes cell proliferation and invasion by targeting FBXW7

C Zhou, L Shen, L Mao, B Wang, Y Li, H Yu - Biochemical and biophysical …, 2015 - Elsevier
MicroRNAs (miRNAs) are involved in the cervical carcinogenesis and progression. In this
study, we investigated the role of miR-92a in progression and invasion of cervical cancer …

For better or worse: modulation of the host DNA damage response by human papillomavirus

CJ Studstill, CA Moody - Annual review of virology, 2023 - annualreviews.org
High-risk human papillomaviruses (HPVs) are associated with several human cancers.
HPVs are small, DNA viruses that rely on host cell machinery for viral replication. The HPV …

Eleven genes associated with progression and prognosis of endometrial cancer (EC) identified by comprehensive bioinformatics analysis

JH Liu, SL Zhou, SY Li, Y Jiang, YC Wan, XL Ma… - Cancer Cell …, 2019 - Springer
Background Endometrial cancer (EC) is one of the female malignant tumors. Endometrial
cancer predominately affects post-menopausal women. Bioinformatics analysis has been …