Acute respiratory distress syndrome (ARDS) is a syndrome of acute respiratory failure
caused by noncardiogenic pulmonary edema. Despite five decades of basic and clinical …

Earlier research primarily attributed the effects of mesenchymal stem cell (MSC) therapies to
their capacity for local engrafting and differentiating into multiple tissue types. However …

Improving the immunomodulatory efficacy of mesenchymal stem cells (MSCs) through
pretreatment with pro-inflammatory cytokines is an evolving field of investigation. However …

Human mesenchymal stem cells (MSCs) are multilineage somatic progenitor/stem cells that
have been shown to possess immunomodulatory properties in recent years. Initially met with …

Rationale: Microvesicles (MVs) are anuclear fragments of cells released from the endosomal
compartment or shed from surface membranes. We and other investigators demonstrated …

Tissue regeneration by stem cells is driven by the paracrine activity of shedding vesicles and
exosomes, which deliver specific cargoes to the recipient cells. Proteins, RNA, cytokines and …

Background We previously reported that microvesicles (MVs) released by human
mesenchymal stem cells (MSC) were as effective as the cells themselves in both …

Endothelial barrier integrity is required for maintaining vascular homeostasis and fluid
balance between the circulation and surrounding tissues and for preventing the …

Although significant advances have been made in synthetic nerve conduits and surgical
techniques, complete regeneration following peripheral nerve injury (PNI) remains far from …

The literature provides abundant evidence that mesenchymal stem cells (MSCs) are an
attractive resource for therapeutics and have beneficial effects in regenerating injured …