The development of novel therapeutic approaches is necessary to manage gastrointestinal
cancers (GICs). Considering the effective molecular mechanisms involved in tumor growth …

Fibrosis is the abnormal accumulation of extracellular matrix proteins such as collagen and
fibronectin. Aging, injury, infections, and inflammation can cause different types of tissue …

Eukaryotes initiate autophagy when facing environmental changes such as a lack of
external nutrients. However, the mechanisms of autophagy initiation are still not fully …

Pulmonary fibrosis (PF) is a life-threatening disorder that severely disrupts normal lung
architecture and function, resulting in severe respiratory failure and death. It has no definite …

Systemic sclerosis (SSc) is an autoimmune disease characterised by microvasculopathy,
immune dysregulation, and skin and visceral organ fibrosis. Every year novel insights into …

Pulmonary fibrosis (PF) is a serious and often fatal illness that occurs in various clinical
settings and represents a significant unmet medical need. Increasing evidence indicates that …

Fibrotic diseases impose a major socioeconomic challenge on modern societies and have
limited treatment options. Adropin, a peptide hormone encoded by the energy homeostasis …

Adipose tissues in the hypodermis, the crucial stem cell reservoir in the skin and the
endocrine organ for the maintenance of skin homeostasis undergo significant changes …

Tumors not only consist of cancerous cells, but they also harbor several normal-like cell
types and non-cellular components. Carcinoma-associated fibroblasts (CAFs) are one of …

Fibrosis involving the lung may occur in many settings, including in association with known
environmental agents, connective tissue diseases, and exposure to drugs or radiation …