The hypothalamic-pituitary-adrenal (HPA) axis is involved in the pathophysiology of many
neuropsychiatric disorders. Increased HPA axis activity can be observed during chronic …

Geriatric depression is a major public health problem and has an especially large effect on
health when comorbid with a chronic medical condition. Hypertension, coronary heart …

Depressive disorders (DDs) are one of the most widespread forms of psychiatric pathology.
According to the World Health Organization, about 350 million people in the world are …

Neurogenesis in adult humans remains a controversial area of research among
neuroscientists. Methodological challenges have hampered investigators from conducting …

Among the chaperones and co-chaperones regulating the glucocorticoid receptor (GR),
FK506 binding protein (FKBP) 51 is the most intensely investigated across different …

Depression is a prevalent disease worldwide, limiting psychosocial functioning and
thequality of life. Linalool is the main constituent of some essential oils from aromatic plants …

The limited effects of currently available antidepressants are becoming an urgent issue in
depression research. It takes a long time to determine treatment effects, and the overall …

Depression is a serious widespread psychiatric disorder that affects approximately 17% of
people all over the world. Exploring the neurological mechanisms of the antidepressant …

Agmatine, an endogenous neuromodulator, is a potential candidate to constitute an
adjuvant/monotherapy for the management of depression. A recent study by our group …

Major depression is a serious psychiatric disorder; however, the precise biological basis of
depression still remains elusive. A large body of evidence implicates a dysregulated …