[HTML][HTML] Progress in antimelanoma research of natural triterpenoids and their derivatives: mechanisms of action, bioavailability enhancement and structure …
M Grudzińska, B Stachnik, A Galanty, A Sołtys… - Molecules, 2023 - mdpi.com
Melanoma is one of the most dangerous forms of skin cancer, characterized by early
metastasis and rapid development. In search for effective treatment options, much attention …
metastasis and rapid development. In search for effective treatment options, much attention …
[HTML][HTML] 22β-hydroxytingenone induces apoptosis and suppresses invasiveness of melanoma cells by inhibiting MMP-9 activity and MAPK signaling
ESP Aranha, AJ de Sousa Portilho, LB de Sousa… - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance 22β-hydroxytingenone (22-HTG) is a
quinonemethide triterpene isolated from Salacia impressifolia (Miers) AC Smith (family …
quinonemethide triterpene isolated from Salacia impressifolia (Miers) AC Smith (family …
[HTML][HTML] Tingenone and 22-hydroxytingenone target oxidative stress through downregulation of thioredoxin, leading to DNA double-strand break and JNK/p38 …
ACBC Rodrigues, LM Bomfim, SP Neves… - Biomedicine & …, 2021 - Elsevier
Acute myeloid leukemia (AML) is the most lethal form of leukemia. Standard anti-AML
treatment remains almost unchanged for decades. Tingenone (TG) and 22 …
treatment remains almost unchanged for decades. Tingenone (TG) and 22 …
Differences in glucose concentration shows new perspectives in gastric cancer metabolism
EL da Silva, FP Mesquita, AJ de Sousa Portilho… - Toxicology in Vitro, 2022 - Elsevier
Gastric cancer (GC) is among the deadliest cancers worldwide despite available therapies,
highlighting the need for novel therapies and pharmacological agents. Metabolic …
highlighting the need for novel therapies and pharmacological agents. Metabolic …
Evaluation of different models of tumor spheroid generation with CAL27 cells
L de Sousa Mendonça, LLM da Silva Dias… - Peer Review, 2023 - peerw.org
In cancer research, three-dimensional cell culture models have become useful tools for
investigating the tumor microenvironment, cancer stages, and the search for new therapeutic …
investigating the tumor microenvironment, cancer stages, and the search for new therapeutic …
Estabelecimento de modelo de carcinoma in situ para estudos de microambiente tumoral in vitro
LS Mendonça - 2023 - tede.ufam.edu.br
Os modelos de cultura celular tridimensional in vitro estão cada vez mais conhecidos e
aplicáveis nos laboratórios de pesquisa, devido a sua capacidade de mimetizar as …
aplicáveis nos laboratórios de pesquisa, devido a sua capacidade de mimetizar as …
[HTML][HTML] Expressão de AKR1B10 e os efeitos citotóxicos da 22β-hidroxitingenona em carcinoma de células escamosas
K Parente, L Mendonça, T Machado, É Aranha… - Peer Review, 2023 - peerw.org
O câncer de língua provocado por carcinoma de células escamosas é um tipo de tumor de
alta letalidade. Análises in silico demonstraram que genes como o AKR1B10 estão …
alta letalidade. Análises in silico demonstraram que genes como o AKR1B10 estão …
Efeito antitumoral de 22β-hidroxitingenona obtida de Salacia impressifolia (Miers) AC (Celastraceae) contra células de melanoma humano
ESP Aranha - 2020 - tede.ufam.edu.br
RESUMO O melanoma é um tipo de câncer de pele com elevada capacidade metastática e
significativa resistência tumoral aos tratamentos disponíveis. A busca por novas opções …
significativa resistência tumoral aos tratamentos disponíveis. A busca por novas opções …