Natural killer (NK) cells are innate lymphocytes that are crucial for the control of infections
and malignancies. NK cells express a variety of inhibitory and activating receptors that …

The implementation of immune checkpoint inhibitors to the oncology clinic signified a new
era in cancer treatment. After the first indication of melanoma, an increasing list of additional …

Human NK cells can be subdivided into various subsets based on the relative expression of
CD16 and CD56. In particular, CD56 bright CD16−/dim NK cells are the focus of interest …

Cancer immunoediting explains the dual role by which the immune system can both
suppress and/or promote tumor growth. Although cancer immunoediting was first …

The mammalian target of rapamycin complex 1 (mTORC1) is a key regulator of cellular
metabolism and also has fundamental roles in controlling immune responses. Emerging …

Natural killer cells are important effector lymphocytes of the innate immune system, playing
critical roles in antitumor and anti-infection host defense. Tumor progression or chronic …

Abstract CD96, CD226 (DNAM-1) and TIGIT belong to an emerging family of receptors that
interact with nectin and nectin-like proteins. CD226 activates natural killer (NK) cell …

Purpose: Natural killer (NK) cells play a critical role in tumor immunosurveillance. Multiple
activating and inhibitory receptors (IR) regulate NK-cell–mediated tumor control. The IR T …

Simple Summary Natural killer cells are innate cytotoxic lymphocytes that play a key role in
the anti-tumor immune response. In the tumor microenvironment, however, the effector …

The ability of tumors to manage an immune‐mediated attack has been recently included in
the “next generation” of cancer hallmarks. In solid tumors, the microenvironment that is …