Transforming growth factor-β (TGF-β) signaling is an important pathway for promoting the
pathogenesis of inflammatory diseases, including cancer. The roles of TGF-β signaling are …

Natural killer (NK) cells are innate lymphoid cells that hold tremendous potential for effective
immunotherapy for a broad range of cancers. Due to the mode of NK cell killing, requiring …

Protection against cellular stress from various sources, such as nutritional, physical,
pathogenic, or oncogenic, results in the induction of both intrinsic and extrinsic cellular …

Inhibitory leukocyte immunoglobulin-like receptors (LILRBs 1-5) transduce signals via
intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that recruit protein …

During different stages of tumor development the immune system can either identify and
destroy tumors, or promote their growth. Therapies targeting the immune system have …

Human cytomegalovirus (HCMV) infection exerts broad effects on the immune system.
These include the differentiation and persistent expansion of a mature NK cell subset which …

Defects in natural killer (NK) cell functions are necessary for tumor immune escape, but their
underlying regulatory mechanisms in human cancers remain largely unknown. Here we …

Abstract Purpose: Natural killer (NK)-cell recognition and function against NK-resistant
cancers remain substantial barriers to the broad application of NK-cell immunotherapy …

As limited information is available regarding the distribution and trafficking of NK cells
among solid organs, we have analyzed a wide array of tissues derived from different human …

Inflammation is now recognized as a hallmark of cancer. Genetic changes in the cancer cell
are accepted as the match that lights the fire, whilst inflammation is seen as the fuel that …