Natural killer (NK) cells, the prototypic member of innate lymphoid cells, are important
effectors of anticancer immune response. These cells can survey and control tumor initiation …

Cellular senescence is a tumor-suppressive mechanism that can paradoxically contribute to
aging pathologies. Despite evidence of immune clearance in mouse models, it is not known …

Triple-negative breast cancer (TNBC), representing~ 15% of globally diagnosed breast
cancer, is typically an incurable malignancy due to the lack of targetable surface targets for …

Background Natural killer (NK) cells play a crucial role in tumor immunosurveillance through
their cytotoxic effector functions and their capacity to interact with other immune cells to build …

Hepatocellular carcinoma (HCC) is currently the third leading cause of cancer mortality and
a common poor-prognosis malignancy due to postoperative recurrence and metastasis …

Purpose: Treatment of breast cancer has been increasingly successful in recent years with
the advent of HER2-receptor targeted treatment and endocrine treatment. However, the …

A phase 1 study of lirilumab (antibody against killer immunoglobulin-like receptor antibody
KIR2D; IPH2102) in patients with solid tumors and hematologic malignancies - PMC Back to …

Natural killer (NK) cells are innate cytotoxic lymphocytes involved in the surveillance and
elimination of cancer. As we have learned more and more about the mechanisms NK cells …

The global outbreak of coronavirus-2019 (COVID-19) still claims more lives daily around the
world due to the lack of a definitive treatment and the rapid tendency of virus to mutate …

The tumor microenvironment (TME) is a complex and heterogeneous environment
composed of cancer cells, tumor stroma, a mixture of tissue-resident and infiltrating immune …