Chemokine networks modulating natural killer cell trafficking to solid tumors
X Yao, S Matosevic - Cytokine & growth factor reviews, 2021 - Elsevier
Natural killer (NK) cell-based cell therapy has been emerging as a powerful weapon in the
treatment of multiple malignancies. However, the inadequate infiltration of the therapeutic …
treatment of multiple malignancies. However, the inadequate infiltration of the therapeutic …
Harnessing NK cells for cancer treatment
In the last years, natural killer (NK) cell-based immunotherapy has emerged as a promising
therapeutic approach for solid tumors and hematological malignancies. NK cells are innate …
therapeutic approach for solid tumors and hematological malignancies. NK cells are innate …
Tertiary lymphoid structure-associated B cells are key players in anti-tumor immunity
C Germain, S Gnjatic, MC Dieu-Nosjean - Frontiers in immunology, 2015 - frontiersin.org
It is now admitted that the immune system plays a major role in tumor control. Besides the
existence of tumor-specific T cells and B cells, many studies have demonstrated that high …
existence of tumor-specific T cells and B cells, many studies have demonstrated that high …
Comprehensive analysis of the percentage of surface receptors and cytotoxic granules positive natural killer cells in patients with pancreatic cancer, gastric cancer …
YP Peng, Y Zhu, JJ Zhang, ZK Xu, ZY Qian… - Journal of translational …, 2013 - Springer
Background Digestive malignancies, especially pancreatic cancer (PC), gastric cancer (GC),
and colorectal cancer (CRC), still occur at persistently high rates, and disease progression …
and colorectal cancer (CRC), still occur at persistently high rates, and disease progression …
The TGF-β/SMAD pathway is an important mechanism for NK cell immune evasion in childhood B-acute lymphoblastic leukemia
RH Rouce, H Shaim, T Sekine, G Weber, B Ballard… - Leukemia, 2016 - nature.com
Natural killer (NK) cells are key components of the innate immune system, providing potent
antitumor immunity. Here, we show that the tumor growth factor-β (TGF-β)/SMAD signaling …
antitumor immunity. Here, we show that the tumor growth factor-β (TGF-β)/SMAD signaling …
Rapid development of exhaustion and down-regulation of eomesodermin limit the antitumor activity of adoptively transferred murine natural killer cells
S Gill, AE Vasey, A De Souza, J Baker… - Blood, The Journal …, 2012 - ashpublications.org
Natural killer (NK) cells are potent anti-viral and antitumor “first responders” endowed with
natural cytotoxicity and cytokine production capabilities. To date, attempts to translate these …
natural cytotoxicity and cytokine production capabilities. To date, attempts to translate these …
Human natural killer cells: origin, receptors, function, and clinical applications
Natural killer (NK) cells are important effectors playing a relevant role in innate immunity,
primarily in tumor surveillance and in defenses against viruses. Human NK cells recognize …
primarily in tumor surveillance and in defenses against viruses. Human NK cells recognize …
Tumor-educated Tregs drive organ-specific metastasis in breast cancer by impairing NK cells in the lymph node niche
Breast cancer is accompanied by systemic immunosuppression, which facilitates metastasis
formation, but how this shapes organotropism of metastasis is poorly understood. Here, we …
formation, but how this shapes organotropism of metastasis is poorly understood. Here, we …
The rise of NK cell checkpoints as promising therapeutic targets in cancer immunotherapy
H Sun, C Sun - Frontiers in immunology, 2019 - frontiersin.org
Checkpoint immunotherapy that targets inhibitory receptors of T cells, thereby reversing the
functional exhaustion of T cells, marks a breakthrough in anticancer therapy. The success of …
functional exhaustion of T cells, marks a breakthrough in anticancer therapy. The success of …
Natural Killer Cell Engagers (NKCEs): a new frontier in cancer immunotherapy
Natural Killer (NK) cells are a type of innate lymphoid cells that play a crucial role in
immunity by killing virally infected or tumor cells and secreting cytokines and chemokines …
immunity by killing virally infected or tumor cells and secreting cytokines and chemokines …