Natural killer (NK) cell-based cell therapy has been emerging as a powerful weapon in the
treatment of multiple malignancies. However, the inadequate infiltration of the therapeutic …

In the last years, natural killer (NK) cell-based immunotherapy has emerged as a promising
therapeutic approach for solid tumors and hematological malignancies. NK cells are innate …

It is now admitted that the immune system plays a major role in tumor control. Besides the
existence of tumor-specific T cells and B cells, many studies have demonstrated that high …

Background Digestive malignancies, especially pancreatic cancer (PC), gastric cancer (GC),
and colorectal cancer (CRC), still occur at persistently high rates, and disease progression …

Natural killer (NK) cells are key components of the innate immune system, providing potent
antitumor immunity. Here, we show that the tumor growth factor-β (TGF-β)/SMAD signaling …

Natural killer (NK) cells are potent anti-viral and antitumor “first responders” endowed with
natural cytotoxicity and cytokine production capabilities. To date, attempts to translate these …

Natural killer (NK) cells are important effectors playing a relevant role in innate immunity,
primarily in tumor surveillance and in defenses against viruses. Human NK cells recognize …

Breast cancer is accompanied by systemic immunosuppression, which facilitates metastasis
formation, but how this shapes organotropism of metastasis is poorly understood. Here, we …

Checkpoint immunotherapy that targets inhibitory receptors of T cells, thereby reversing the
functional exhaustion of T cells, marks a breakthrough in anticancer therapy. The success of …

Natural Killer (NK) cells are a type of innate lymphoid cells that play a crucial role in
immunity by killing virally infected or tumor cells and secreting cytokines and chemokines …