Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and
anabolism to generate cellular energy and structural components. The emerging field of …

Iron is a critical metal for several vital biological processes. Most of the body's iron is bound
to hemoglobin in erythrocytes. Iron from senescent red blood cells is recycled by …

Abstract Haem oxygenase 1 (HO-1), an inducible enzyme responsible for the breakdown of
haem, is primarily considered an antioxidant, and has long been overlooked by …

Metazoan tissue specification is associated with integration of macrophage lineage cells in
sub-tissular niches to promote tissue development and homeostasis. Oncogenic …

Melanoma brain metastasis (MBM) frequently occurs in patients with advanced melanoma;
yet, our understanding of the underlying salient biology is rudimentary. Here, we performed …

Inflammation is usually considered as harmful; however, it is also necessary for tissue
recovery after injury. Macrophages exert immune and nonimmune functions throughout this …

High iron is a risk factor for type 2 diabetes mellitus (T2DM) and affects most of its cardinal
features: decreased insulin secretion, insulin resistance, and increased hepatic …

Ferroptosis is a newly defined form of regulated cell death (RCD) characterized by iron
overload, lipid reactive oxygen species (ROS) accumulation, and lipid peroxidation, which is …

Iron is critical for the appearance and maintenance of life on Earth. Almost all organisms
compete or cooperate for iron acquisition, demonstrating the importance of this essential …

Hyperferritinaemia is a common laboratory finding that is often associated with metabolic
dysfunction and fatty liver. Metabolic hyperferritinaemia reflects alterations in iron …