How I treat early-relapsing follicular lymphoma

C Casulo, PM Barr - Blood, The Journal of the American Society …, 2019 - ashpublications.org
Follicular lymphoma (FL) is the most frequently occurring indolent non-Hodgkin lymphoma,
with generally favorable outcomes but a variable clinical course. Recent studies have …

[HTML][HTML] Unmet needs in the first-line treatment of follicular lymphoma

C Casulo, L Nastoupil, NH Fowler, JW Friedberg… - Annals of …, 2017 - Elsevier
For the majority of patients with newly diagnosed follicular lymphoma (FL), current
treatments, while not curative, allow for long remission durations. However, several …

Progression of disease within 24 months in follicular lymphoma is associated with reduced intratumoral immune infiltration

JWD Tobin, C Keane, J Gunawardana… - Journal of Clinical …, 2019 - ascopubs.org
PURPOSE Understanding the immunobiology of the 15% to 30% of patients with follicular
lymphoma (FL) who experience progression of disease within 24 months (POD24) remains …

Prognostic model for high-tumor-burden follicular lymphoma integrating baseline and end-induction PET: a LYSA/FIL study

AS Cottereau, A Versari, S Luminari… - Blood, The Journal …, 2018 - ashpublications.org
Both total metabolic tumor volume (TMTV), computed on baseline positron emission
tomography (PET), and end of induction (EOI) PET are imaging biomarkers showing …

Multi-omic profiling of follicular lymphoma reveals changes in tissue architecture and enhanced stromal remodeling in high-risk patients

AJ Radtke, E Postovalova, A Varlamova, A Bagaev… - Cancer cell, 2024 - cell.com
Follicular lymphoma (FL) is a generally incurable malignancy that evolves from
developmentally blocked germinal center (GC) B cells. To promote survival and immune …

T cells expressing checkpoint receptor TIGIT are enriched in follicular lymphoma tumors and characterized by reversible suppression of T-cell receptor signaling

SE Josefsson, K Huse, A Kolstad, K Beiske… - Clinical Cancer …, 2018 - AACR
Purpose: T cells infiltrating follicular lymphoma (FL) tumors are considered dysfunctional, yet
the optimal target for immune checkpoint blockade is unknown. Characterizing coinhibitory …

Targeting MCL‐1 and BCL‐2 with polatuzumab vedotin and venetoclax overcomes treatment resistance in R/R non‐Hodgkin lymphoma: Results from preclinical …

EA Lasater, DN Amin, R Bannerji… - American journal of …, 2023 - Wiley Online Library
The treatment of patients with relapsed or refractory lymphoid neoplasms represents a
significant clinical challenge. Here, we identify the pro‐survival BCL‐2 protein family …

Clinical and antitumor immune responses in relapsed/refractory follicular lymphoma patients after intranodal injections of IFNα-dendritic cells and rituximab: a phase I …

MC Cox, L Castiello, M Mattei, L Santodonato… - Clinical Cancer …, 2019 - AACR
Purpose: This study was aimed at evaluating the feasibility, safety, immunologic and clinical
responses in patients with follicular lymphoma treated with monocyte-derived dendritic cells …

A multi-scale, multiomic atlas of human normal and follicular lymphoma lymph nodes

AJ Radtke, E Postovalova, A Varlamova, A Bagaev… - BioRxiv, 2022 - biorxiv.org
Reference atlases, molecular and spatial maps of mammalian tissues, are critical resources
for discovery efforts and translational research. Their utility is dependent on operationalizing …

The promises and challenges of using gene mutations for patient stratification in follicular lymphoma

O Weigert, DM Weinstock - Blood, The Journal of the American …, 2017 - ashpublications.org
Follicular lymphoma (FL) is a clinically and molecularly highly heterogeneous disease. Most
patients achieve long-lasting remissions and have excellent overall survival (OS) with …