Chirality has a key role in the synthesis of biomolecules and the development of life.
Although the effects of many chiral molecules or materials on biological processes have …

Urea and thiourea represent privileged structures in medicinal chemistry. Indeed, these
moieties constitute a common framework of a variety of drugs and bioactive compounds …

Histone deacetylases (HDACs) are enzymes pursued as drug targets in various cancers and
several non-oncological conditions, such as inflammation and neurodegenerative disorders …

Lead optimization represents the tedious process of fine‐tuning lead compounds from
biologically active hits to suitable drug candidates for clinical trials. By chemically modifying …

Targeting vectors bound to a chelator represent a significant fraction of
radiopharmaceuticals used nowadays for diagnostic and therapeutic purposes in nuclear …

(1) Background: carbonic anhydrases (CAs) are attractive targets for the development of
new anticancer therapies; in particular, CAs IX and XII isoforms are overexpressed in …

This paper described our efforts to develop dianilinopyrimidines as novel EGFR inhibitors.
All the target compounds were tested for inhibitory effects against wild type EGFR (EGFRwt) …

Reported herein is a novel palladium-catalyzed [2+ 2+ 1] domino annulation of 3-
iodochromones, bridged olefins, and dimethyl squarate allowing the construction of …

The direct gem‐difluoroalkenylation of X− H bonds represents the most straightforward
approach to access heteroatomic gem‐difluoroalkenes that, as the isostere of the carbonyl …

The conjugate addition of nitroalkanes to electron-poor alkenes is a widely used process
which only in the late nineties of the last century has efficiently evolved in its asymmetric …