The direct gem‐difluoroalkenylation of X− H bonds represents the most straightforward
approach to access heteroatomic gem‐difluoroalkenes that, as the isostere of the carbonyl …

Catalytic carbene transfer reactions are fundamental transformations in modern organic
synthesis, which enable direct access to diverse structurally complex molecules. Despite …

The glycogen synthase kinase 3β (GSK‐3β) is a ubiquitous enzyme that is a validated target
for the development of potential therapeutics useful in several diseases including retinal …

Dipeptides are minimalistic peptide building blocks that form well ordered structures through
molecular self-assembly. The driving forces involved are cooperative noncovalent …

Bioconjugation reactions are critical to the modification of peptides and proteins, permitting
the introduction of biophysical probes onto proteins as well as drugs for use in antibody …

DNA-encoded libraries (DELs) can be considered as one of the most powerful tools for the
discovery of small molecules of biological interest. However, the ability to access large DELs …

Alzheimer's disease (AD) is a devastating neurodegenerative condition with complex
pathophysiology. Aggregated amyloid beta (Aβ) peptide plaques and higher concentrations …

We have quantum chemically analyzed the cooperative effects and structural deformations
of hydrogen‐bonded urea, deltamide, and squaramide linear chains using dispersion …

Herein we report the design, synthesis and assessment of the first example of a squaramide-
based self-immolative system triggered by an enzymatic reduction. We have proved that the …

UDP-Glc: glycoprotein glucosyltransferase (UGGT) has a central role to retain quality control
of correctly folded N-glycoprotein in the endoplasmic reticulum (ER). A selective and potent …