A convenient method has been developed for transforming alkyl halides into the
corresponding alcohols via an SN2 reaction. Treatment of an alkyl halide with the squarate …

Mycobacterial ATP synthase is a validated therapeutic target for combating drug-resistant
tuberculosis. Inhibition of this enzyme has been featured as an efficient strategy for the …

Straightforward and general Passerini and Ugi procedures have been developed to
incorporate four‐membered heterocycles into highly functionalized scaffolds. Additionally …

Within the realm of contemporary medicinal chemistry, bioisosteres are empirically used to
enhance potency and selectivity, improve adsorption, distribution, metabolism, excretion and …

The biological and medicinal chemistry of the oxocarbon acids 2, 3-dihydroxycycloprop-2-en-
1-one (deltic acid), 3, 4-dihydroxycyclobut-3-ene-1, 2-dione (squaric acid), 4, 5-dihydroxy-4 …

Three new monosquaramides (3a–c) were synthesized, characterized by IR, NMR and X-
ray, and evaluated for inhibitory activity against deoxyribonuclease I (DNase I) and xanthine …

In this review, we summarize the data about applications of squaric acid, its derivatives and
their metal complexes in medicine. In recent years, researchers have been concentrated on …

This perspective is an attempt to document the problems that medicinal chemists are facing
in drug discovery. It is also trying to identify relevant/possible, research areas in which …

New inhibitors of the bacterial tranferase MraY are described. Their structure is based on an
aminoribosyl uridine scaffold, which is known to be important for the biological activity of …

Solubility is a crucial encumbrance for the synthesis of squaramides through nucleophilic
substitution of squaric acid. The reactions must be performed in an aqueous medium since …