Leptospira is a highly heterogeneous bacterial genus that can be divided into three
evolutionary lineages and> 300 serovars. The causative agents of leptospirosis are …

Bacterial genomes can contain traces of a complex evolutionary history, including extensive
homologous recombination, gene loss, gene duplications, and horizontal gene transfer. To …

Computational pan-genome analysis has emerged from the rapid increase of available
genome sequencing data. Starting from a microbial pan-genome, the concept has spread to …

Porphyromonas gingivalis is a keystone pathogen of chronic periodontitis. The virulence of
P. gingivalis is reported to be strain related and there are currently a number of strain typing …

Corynebacterium diphtheriae is highly transmissible and can cause large diphtheria
outbreaks where vaccination coverage is insufficient. Sporadic cases or small clusters are …

Complexes of physically interacting proteins constitute fundamental functional units that
drive almost all biological processes within cells. A faithful reconstruction of the entire set of …

Background Development of drug resistance in bacteria causes antibiotic therapies to be
less effective and more costly. Moreover, our understanding of the process remains …

Due to their tendency to have a high recombination rate, bacterial genomes are highly
diverse across different strains. This diversity may even be in the form of the presence or …

Staphylococcus epidermidis is a pathogen emerging worldwide as a leading cause of health
care-associated infections. A standardized high-resolution typing method to document …

Streptococcus pneumoniae (pneumococcus) is one of the leading causes of mortality in
Africa. It asymptomatically colonizes the human nasopharynx. The invasive pneumococcal …