Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson's disease and Alzheimer's disease

T Jiang, Q Sun, S Chen - Progress in neurobiology, 2016 - Elsevier
Oxidative stress reflects an imbalance between the overproduction and incorporation of free
radicals and the dynamic ability of a biosystem to detoxify reactive intermediates. Free …

Disease-associated regulation of gene expression by resveratrol: Special focus on the PI3K/AKT signaling pathway

S Ghafouri-Fard, Z Bahroudi, H Shoorei… - Cancer Cell …, 2022 - Springer
Abstract Resveratrol (3, 5, 4′-trihydroxy-trans-stilbene) is a natural phenol that is present in
the skin of the grape, blueberry, raspberry, mulberry, and peanut. This substance is …

[HTML][HTML] Resveratrol inhibits proliferation and migration through SIRT1 mediated post‑translational modification of PI3K/AKT signaling in hepatocellular carcinoma …

R Chai, H Fu, Z Zheng, T Liu… - Molecular medicine …, 2017 - spandidos-publications.com
Resveratrol (RES), a polyphenolic compound present in grapes and red wine, has potential
anticancer properties. The present study aimed to examine the effects of resveratrol and its …

Resveratrol ameliorates hyperglycemia-induced renal tubular oxidative stress damage via modulating the SIRT1/FOXO3a pathway

X Wang, L Meng, L Zhao, Z Wang, H Liu, G Liu… - Diabetes research and …, 2017 - Elsevier
Aims Oxidative stress plays an important role in the development and progression of
diabetic nephropathy (DN). We aimed to investigate if resveratrol (RSV) could ameliorate …

Targeting cellular senescence in cancer by plant secondary metabolites: A systematic review

S Fakhri, SZ Moradi, A Ash-Rafzadeh… - Pharmacological …, 2022 - Elsevier
Senescence suppresses tumor growth, while also developing a tumorigenic state in the
nearby cells that is mediated by senescence-associated secretory phenotypes (SASPs). The …

Therapeutic role of sirtuins in neurodegenerative disease and their modulation by polyphenols

M Ajami, H Pazoki-Toroudi, H Amani, SF Nabavi… - Neuroscience & …, 2017 - Elsevier
Searching for effective therapeutic agents‏‎ to‎‏ prevent‏‏ neurodegeneration‎ is a challenging
task due‎ to‎ the growing list of neurodegenerative disorders associated with a multitude of …

Alpha-lipoic acid activates AMPK to protect against oxidative stress and apoptosis in rats with diabetic peripheral neuropathy

T Zhang, D Zhang, Z Zhang, J Tian, J An, W Zhang… - Hormones, 2023 - Springer
Purpose To investigate the AMPK pathway–mediated effect of alpha-lipoic acid (ALA) on the
dorsal root ganglia (DRGs) of rats with diabetic peripheral neuropathy (DPN) and to attempt …

Protective effects of Vitis vinifera (grapes) and one of its biologically active constituents, resveratrol, against natural and chemical toxicities: A comprehensive review

J Tabeshpour, S Mehri… - Phytotherapy …, 2018 - Wiley Online Library
Vitis vinifera (grape) is one of the “most‐produced fruit” in the world. Grape seeds are a
valuable source of phenolic compounds including resveratrol (RSV). Grape and one of its …

Resveratrol mitigates oxygen and glucose deprivation-induced inflammation, NLRP3 inflammasome, and oxidative stress in 3D neuronal culture

MC Chiang, CJB Nicol, SS Lo, SW Hung… - International Journal of …, 2022 - mdpi.com
Oxygen glucose deprivation (OGD) can produce hypoxia-induced neurotoxicity and is a
mature in vitro model of hypoxic cell damage. Activated AMP-activated protein kinase …

[HTML][HTML] Inhibition of FOXO3a/BIM signaling pathway contributes to the protective effect of salvianolic acid A against cerebral ischemia/reperfusion injury

J Song, W Zhang, J Wang, H Yang, Q Zhou… - … Pharmaceutica Sinica B, 2019 - Elsevier
Salvianolic acid A (SalA) is an effective compound extracted from traditional Chinese
medicine Salvia miltiorrhiza Bunge. The Forkhead box O3a (FOXO3a) signaling pathway …