Lipids are essential metabolites, which function as energy sources, structural components
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …

Lipids are essential constituents for malignant tumors, as they are absolutely required for
tumor growth and dissemination. Provided by the tumor microenvironment (TME) or by …

The prominent pathological feature of fatty liver disease lesions is excessive fat
accumulation in lipid droplets in hepatocytes. Thus, developing fluorescent lipid droplet …

Exercise can prevent osteoporosis and improve immune function, but the mechanism
remains unclear. Here, we show that exercise promotes reticulocalbin-2 secretion from the …

While the distant organ environment is known to support metastasis of primary tumors, its
metabolic roles in this process remain underdetermined. Here, in breast cancer models, we …

Body fat distribution is a heritable risk factor for cardiovascular and metabolic disease. In
humans, rare Inhibin beta E (INHBE, activin E) loss-of-function variants are associated with a …

Ceramides are a heterogeneous group of bioactive membrane sphingolipids that play
specialized regulatory roles in cellular metabolism depending on their characteristic fatty …

The health concerns of microplastics (MPs) and nanoplastics (NPs) surge, but the key
indicators to evaluate the adverse risks of MPs/NPs are elusive. Recently, MPs/Ps were …

Adipose tissue undergoes thermogenic remodeling in response to thermal stress and
metabolic cues, playing a crucial role in regulating energy expenditure and metabolic …

Thermogenesis by uncoupling protein 1 (UCP1) is one of the primary mechanisms by which
brown adipose tissue (BAT) increases energy expenditure. UCP1 resides in the inner …