Saccular unruptured intracranial aneurysms (UIAs) have a prevalence of 3% in the adult
population, and are being increasingly detected because of improved quality and higher …

OBJECTIVE Unruptured intracranial aneurysms (UIAs) are relatively common lesions that
may cause devastating intracranial hemorrhage, thus producing considerable suffering and …

Figure. Cerebral aneurysm (CA) formation and rupture. Aneurysm formation is initiated by
hemodynamically triggered endothelial dysfunction. An inflammatory response implicating …

Saccular intracranial aneurysms (sIA) are pouch-like pathological dilatations of intracranial
arteries that develop when the cerebral artery wall becomes too weak to resist …

Hypoxia-inducible factors (HIFs) regulate the transcription of genes that mediate the
response to hypoxia. HIFs are constantly expressed and degraded under normoxia, but …

Intracranial aneurysms (IAs) linger as a potentially devastating clinical problem. Despite
intense investigation, our understanding of the mechanisms leading to aneurysm …

Background There seems to be a pathogenetic link between hemodynamics and
inflammatory arterial wall alteration leading to the development and rupture of intracranial …

Background Although microglia and the Toll-like receptor (TLR) pathway have long been
thought to play a role in the pathogenesis of aneurysmal subarachnoid hemorrhage (aSAH) …

Oxidative stress is known to contribute to the progression of cerebrovascular disease.
Additionally, oxidative stress may be increased by, but also augment inflammation, a key …

BACKGROUND: Hypoxia may contribute to the pathogenesis of various diseases of the
vascular wall. Hypoxia-inducible factors (HIFs) are nuclear transcriptional factors that …