The blood–brain barrier (BBB) is a critical biological structure that prevents damage to the
brain and maintains its bathing microenvironment. However, this barrier is also the obstacle …

ABC (ATP-binding cassette) transporters represent one of the largest and most diverse
superfamily of proteins in living species, playing an important role in many biological …

As blood–brain barrier (BBB) disruption emerges as a common problem in the early stages
of neurodegenerative diseases, the crucial roles of barrier-type brain endothelial cells …

Astrocytes are essential for proper regulation of the central nervous system (CNS).
Importantly, these cells are highly secretory in nature. Indeed they can release hundreds of …

The blood–brain barrier (BBB) is a highly selective and restrictive semipermeable network of
cells and blood vessel constituents. All components of the neurovascular unit give to the …

The recent approval of edaravone has provided an intravenous option to treat amyotrophic
lateral sclerosis (ALS) in addition to the existing oral agent, riluzole. The present work was …

In amyotrophic lateral sclerosis (ALS), upregulation in expression and activity of the ABC
transporter P-glycoprotein (P-gp) driven by disease advancement progressively reduces …

Background Hypertriglyceridemia is closely linked to atherosclerosis related inflammatory
processes and blood–brain barrier (BBB) dysfunction. Using apolipoprotein B-100 (APOB …

Introduction Recent studies have implicated changes in the blood-central nervous system
barriers (BCNSB) in amyotrophic lateral sclerosis (ALS). The objective of this scoping review …

The blood-brain-barrier (BBB) has a major function in maintaining brain homeostasis by
regulating the entry of molecules from the blood to the brain. Key players in BBB function are …