In several murine models of autoimmune arthritis, Th17 cells are the dominant initiators of
inflammation. In human arthritis the majority of IL-17–secreting cells within the joint express …

Chemokines and their receptors play an important role in the recruitment, activation and
differentiation of immune cells. The chemokine receptor, CXCR3, and its ligands, CXCL9 …

Multiple sclerosis is a T cell-mediated demyelinating disease of the central nervous system.
Interleukin-17-producing T helper cells, named Th17 cells, represent a novel CD4+ T cell …

Antimicrobial peptides are small molecules with activity against bacteria, yeasts, fungi,
viruses, bacteria, and even tumor cells that make these molecules attractive as therapeutic …

A better understanding of immune-mediated mechanisms in the pathogenesis of multiple
sclerosis and the contribution of environmental risk factors toward the development of …

Lung complications are a major cause of rheumatoid arthritis-related mortality. Involvement
of gut microbiota in lung diseases by the gut-lung axis has been widely observed, but the …

Accumulation of IL-17–producing Th17 cells is associated with the development of multiple
autoimmune diseases; however, the contribution of microRNA (miRNA) pathways to the …

IL-17–producing CD8+ T (Tc17) cells are detectible in multiple sclerosis (MS) lesions;
however, their contribution to the disease is unknown. To identify functions of Tc17 cells, we …

We report that like other T cells cultured in the presence of transforming growth factor (TGF)
β, Th17 cells also produce interleukin (IL) 9. Th17 cells generated in vitro with IL-6 and TGF …

The delicate microenvironment of the central nervous system (CNS) is protected by the
blood–brain barrier (BBB) and the blood–cerebrospinal fluid barrier (BCB). These barriers …