TGFβ pathway inhibition in the treatment of non-small cell lung cancer

PÖ Eser, PA Jänne - Pharmacology & therapeutics, 2018 - Elsevier
Advanced non-small cell lung cancer (NSCLC) continues to be an incurable family of
thoracic malignancies that is chronically managed with chemotherapy, targeted therapy, and …

[HTML][HTML] Drug eluting stents for malignant airway obstruction: a critical review of the literature

W Hohenforst-Schmidt, P Zarogoulidis, G Pitsiou… - Journal of …, 2016 - ncbi.nlm.nih.gov
Lung cancer being the most prevalent malignancy in men and the 3 rd most frequent in
women is still associated with dismal prognosis due to advanced disease at the time of …

[HTML][HTML] Ginsenoside Rg3 inhibits epithelial-mesenchymal transition (EMT) and invasion of lung cancer by down-regulating FUT4

L Tian, D Shen, X Li, X Shan, X Wang, Q Yan, J Liu - Oncotarget, 2016 - ncbi.nlm.nih.gov
The epithelial-mesenchymal transition (EMT) is an important factor in lung cancer
metastasis, and targeting EMT is a potential therapeutic strategy. Fucosyltransferase IV …

Ginsenoside Rg3 sensitizes hypoxic lung cancer cells to cisplatin via blocking of NF-κB mediated epithelial–mesenchymal transition and stemness

J Wang, L Tian, MN Khan, L Zhang, Q Chen, Y Zhao… - Cancer Letters, 2018 - Elsevier
Cisplatin is a first line chemotherapy in lung cancer, but decreased susceptibility may limit its
application. In solid tumors, hypoxia alters the microenvironment and is associated with …

Natural compound allicin containing thiosulfinate moieties as transmembrane protein 16A (TMEM16A) Ion channel inhibitor for food adjuvant therapy of lung cancer

X Bai, Y Cheng, H Wan, S Li, X Kang… - Journal of Agricultural …, 2022 - ACS Publications
Cancer is one of the most serious malignant diseases, and chemotherapy is cancer's main
clinical treatment method. However, chemotherapy inevitably produces drug resistance, and …

Sulforaphane suppresses in vitro and in vivo lung tumorigenesis through downregulation of HDAC activity

LL Jiang, SJ Zhou, XM Zhang, HQ Chen… - Biomedicine & …, 2016 - Elsevier
Background Sulforaphane (SFN), an isothiocyanate isolated from broccoli, has been
reported to have chemopreventive activity. However, the effects of SFN on lung cancer have …

The anticancer activity and mechanisms of ginsenosides: an updated review

H Chen, H Yang, D Fan, J Deng - eFood, 2020 - Wiley Online Library
The annual global mortality rate of cancer has increased dramatically. Although various
therapies are used for cancer, the results have not been satisfactory. Chemotherapy is …

Autophagy accompanied with bisdemethoxycurcumin-induced apoptosis in non-small cell lung cancer cells

JH Xu, HP Yang, XD Zhou, HJ Wang, G Liang… - Biomedical and …, 2015 - Elsevier
Objective To investigate the effects of bisdemethoxycurcumin (BDMC) on non-small cell lung
cancer (NSCLC) cell line, A549, and the highly metastatic lung cancer 95D cells. Methods …

Examination of Combined Treatment of Ginsenoside Rg3 and 5‐Fluorouracil in Lung Adenocarcinoma Cells

K Shan, Y Deng, Z Du, P Yue… - … Mathematical Methods in …, 2022 - Wiley Online Library
Chemotherapy is a commonly used strategy for advanced lung cancer patients. However, its
clinical application is restrained due to its toxicity and drug resistance. Ginsenoside Rg3 …

Inhibitory effect of traditional oriental medicine-derived monoamine oxidase B inhibitor on radioresistance of non-small cell lung cancer

B Son, SY Jun, HJ Seo, HS Youn, HJ Yang, W Kim… - Scientific reports, 2016 - nature.com
Increased survival of cancer cells mediated by high levels of ionizing radiation (IR) reduces
the effectiveness of radiation therapy for non-small cell lung cancer (NSCLC). In the present …