The proteins of the BCL-2 family are key regulators of mitochondrial apoptosis, acting as
either promoters or inhibitors of cell death. The functional interplay and balance between the …

The cystine transporter solute carrier family 7 member 11 (SLC7A11)(also known as xCT)
promotes glutathione synthesis and counters oxidative stress–induced cell death, including …

Disorders of cell number that result from an imbalance between the death of parenchymal
cells and the proliferation or recruitment of maladaptive cells contributes to the pathogenesis …

Pyroptosis is increasingly considered a new weathervane in cancer immune therapy.
However, triggering specific pyroptotic tumor cell death while preserving normal cells still …

Nucleic acid sensing is a central process in the immune system, with far-reaching roles in
antiviral defense, autoinflammation, and cancer. Z-DNA binding protein 1 (ZBP1) is a sensor …

Cell death and inflammation are closely linked arms of the innate immune response to
combat infection and tissue malfunction. Recent advancements in our understanding of the …

Plasma membrane permeabilization (PMP) is a defining feature of regulated necrosis. It
allows the extracellular release of damage-associated molecular patterns (DAMPs) that …

Endoplasmic reticulum (ER)-mitochondria contact sites are crucial to allow Ca 2+ flux
between them and a plethora of proteins participate in tethering both organelles together …

In cancer treatment, the recurrent challenge of inducing apoptosis through conventional
therapeutic modalities, often thwarted by therapy resistance, emphasizes the critical need to …

Lytic cell death triggers an antitumour immune response. However, cancer cells evade lytic
cell death by several mechanisms. Moreover, a prolonged and uncontrolled immune …