Seven new deoxyisoaustamide derivatives (1–7) together with known compounds (8–10)
were isolated from the coral-derived fungus Penicillium dimorphosporum KMM 4689. Their …

Natural products contain bioactive compounds that are produced naturally via synthetic or
semisynthetic processes. These bioactive compounds play significant biological roles …

Gastric cancer is one of the most common, aggressive, and invasive types of malignant
neoplasia. It ranks fifth for incidence and fourth for prevalence worldwide. Products of natural …

Background Hypoxic microenvironment is a common feature of solid tumors, which leads to
the promotion of cancer. The transcription factor, HIF-1α, expressed under hypoxic …

A concise method for the construction of 1‐sulfonyl‐1H‐indoles by the reactions of N‐(2‐
iodoaryl) sulfonamides with calcium carbide is described. The notable features of this …

Drug resistance, including multidrug resistance resulting from different defensive
mechanisms in cancer cells, is the leading cause of the failure of the cancer therapy, posing …

Four monoterpenoid indole alkaloid dimers (MIADs), axidimins AD (1–4), which possesses
unprecedented apidosperma-aspidosperma-type skeletons, along with twelve known MIAs …

The spiroindolenine framework is a privileged heterocyclic motif and is widely present in
numerous indole alkaloids. Herein, we develop a metal-free and environmentally friendly …

Herein, we described the synthesis of indole-tetrazole coupled aromatic amides (6a-o) and
evaluated their in vitro anticancer activity. Some of the compounds namely N-(4 …

Marine-derived bisindoles exhibit structural diversity and exert anti-cancer influence through
multiple mechanisms. Comprehensive research has shown that the development success …