[HTML][HTML] Integrated widely targeted metabolomics and network pharmacology revealed quality disparities between Guizhou and conventional producing areas of …

K Zhang, D Zhang, Q Yang, L Long, J Xie… - Frontiers in …, 2023 - ncbi.nlm.nih.gov
Results The plant traits and DNA barcoding molecular identification results indicated that
Luodang and Weidang from Guizhou were Codonopsis tangshen and Codonopsis pilosula …

Recent advances in the development of nitrogencontaining heterocyclic compounds as anticancer agents: a review

W Ettahiri, M Saber, Z Ouzrour, S Lahmidi… - Moroccan Journal of …, 2023 - revues.imist.ma
N-heterocyclic compounds are a natural and rich source of pharmacologically active
molecules displaying anti-cancer properties through various antiproliferative mechanisms …

Mechanisms of Antitumor Invasion and Metastasis of the Marine Fungal Derivative Epi-Aszonalenin A in HT1080 Cells

Y Liu, L Lin, H Zheng, YL He, Y Li, C Zhou, P Hong… - Marine Drugs, 2023 - mdpi.com
Epi-aszonalenin A (EAA) is an alkaloid that is isolated and purified from the secondary
metabolites of coral symbiotic fungi and has been shown to have good atherosclerotic …

A Review on Indole as a Cardinal Scaffold for Anticancer Drugs Development

M Rana, R Ranjan, N Sekhar Ghosh… - Current Cancer …, 2024 - ingentaconnect.com
Chemotherapy is the mainstay of therapeutic cancer therapy; however, the development of
resistance typically makes it less effective. There are continuous efforts by researchers to …

Synthesis, Characterization and Biological Evaluation of Indole-Pyrazole Amalgamated α-Cyano Substituted Chalcones

PS Bhale, SN Shringare, AB Khade… - Anti-Cancer Agents in …, 2021 - ingentaconnect.com
Background: Indole and pyrazole constitute a major class of biologically active scaffolds.
The amalgamation of two or more pharmacophores would generate novel molecular …

Synthesis and Biological Screening of Novel Indole-derived Imidazo[2,1-b][1,3,4]thiadiazoles as EGFR Targeting Anticancer Agents

S Kuna, J Sandhya, M Raju, S Vasam… - Russian Journal of …, 2023 - Springer
A series of indole-derived imidazo [2, 1-b][1, 3, 4] thiadiazole scaffolds were synthesized,
and their structures were confirmed by 1H and 13C NMR spectroscopy, ESI mass …

The phytochemical compound of Kelantan grown Annona muricata leaves and its anti-proliferative properties on MCF 7 breast cancer cells

N Ismail, H Rajaratinam, KC Ghazali… - Sains …, 2023 - myscholar.umk.edu.my
Annona muricata leaves exhibit anti-cancer properties against breast cancer. In this study,
the phytochemical components, anti-proliferative activity, and cytotoxicity of Kelantan …

Indole/oxazolone functionalized coumarins as pH-sensitive fluorescent kinase inhibitors

A Shamsiya, R Pathoor, D Bahulayan - Tetrahedron Letters, 2022 - Elsevier
A simple MCR-Click strategy for the construction of pH-sensitive fluorescent kinase inhibitors
by scaffolding a coumarin core with an indole or oxazolone moiety is described. The …

The toxicity of Aspidosperma subincanum to MCF7 cells is related to modulation of oxidative status and proinflammatory pathways

AF Santos, NSRS Mota, EM Schiefer… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Cancer is an inflammatory disease because
carcinogenesis and tumor progression depend on intrinsic and extrinsic inflammatory …

Syntheses of Mersicarpine, a Monoterpenoid Indole Alkaloid with an Atypical Tetracyclic Structure

J Xiao, GH Zhou, CB Ji - ChemistrySelect, 2022 - Wiley Online Library
The focus review discusses the synthesis of an important member of the monoterpene
indole alkaloid family, mersicarpine. Biosynthetically, mersicarpine, isolated from the Kopsia …