The impact of respiratory viral infection on wheezing illnesses and asthma exacerbations

KN Carroll, TV Hartert - Immunology and allergy clinics of North America, 2008 - Elsevier
The etiology and morbidity associated with asthma are thought to stem from both genetic
factors and potentially modifiable environmental factors, such as viral infections. Although it …

Human respiratory syncytial virus subgroup A and B infections in nasal, bronchial, small-airway, and organoid-derived respiratory cultures

LC Rijsbergen, MM Lamers, AD Comvalius… - Msphere, 2021 - Am Soc Microbiol
Human respiratory syncytial virus (HRSV) is the leading cause of bronchiolitis in infants. Two
subgroups of HRSV (A and B) routinely cocirculate. Most research has been performed with …

Validity of bronchiolitis outcome measures

RM Fernandes, AC Plint, CB Terwee, C Sampaio… - …, 2015 - publications.aap.org
BACKGROUND: The Respiratory Distress Assessment Instrument (RDAI) and Respiratory
Assessment Change Score (RACS) are frequently used in bronchiolitis clinical trials, but …

Hypertonic saline (HS) for acute bronchiolitis: systematic review and meta-analysis

C Maguire, H Cantrill, D Hind, M Bradburn… - BMC Pulmonary …, 2015 - Springer
Background Acute bronchiolitis is the commonest cause of hospitalisation in infancy.
Currently management consists of supportive care and oxygen. A Cochrane review …

Clinical predictors of admission in infants with acute bronchiolitis

M Marlais, J Evans, E Abrahamson - Archives of disease in childhood, 2011 - adc.bmj.com
Background Bronchiolitis is a significant cause of acute morbidity in the first 12 months of life
and some infants with bronchiolitis are admitted to hospital. No studies have yet devised a …

Antibody responses to respiratory syncytial virus: a cross-sectional serosurveillance study in the Dutch population focusing on infants younger than 2 years

G Berbers, L Mollema, F van der Klis… - The Journal of …, 2021 - academic.oup.com
Background Respiratory syncytial virus (RSV) generally causes mild disease but can cause
severe infections in (premature) infants and elderly adults. Here, we studied RSV-specific …

Neutrophils do not impact viral load or the peak of disease severity during RSV infection

F Kirsebom, C Michalaki, M Agueda-Oyarzabal… - Scientific Reports, 2020 - nature.com
Lung and airway neutrophils are a hallmark of severe disease in infants with respiratory
syncytial virus (RSV)-induced lower respiratory tract infections. Despite their abundance in …

High flow therapy versus hypertonic saline in bronchiolitis: randomised controlled trial

MB Campaña, JO Ortiz, CN Muñoz… - Archives of disease in …, 2014 - adc.bmj.com
Objective To demonstrate that heated humidified high-flow nasal cannula (HHHFNC) is
superior to inhaled hypertonic saline solution (HSS) in improving respiratory distress in …

[HTML][HTML] Control of pathogenic effector T-cell activities in situ by PD-L1 expression on respiratory inflammatory dendritic cells during respiratory syncytial virus infection

S Yao, L Jiang, EK Moser, LB Jewett, J Wright, J Du… - Mucosal …, 2015 - Elsevier
Respiratory syncytial virus (RSV) infection is a leading cause of severe lower respiratory
tract illness in young infants, the elderly and immunocompromised individuals. We …

CD4+ T-cell counts and interleukin-8 and CCL-5 plasma concentrations discriminate disease severity in children with RSV infection

HK Brand, G Ferwerda, F Preijers, R de Groot… - Pediatric …, 2013 - nature.com
Background: Current tools to predict the severity of respiratory syncytial virus (RSV) infection
might be improved by including immunological parameters. We hypothesized that a …