Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …

Alzheimer disease (AD) is the most common form of neurodegenerative disease, estimated
to contribute 60–70% of all cases of dementia worldwide. According to the prevailing …

The brain harbors a unique ability to, figuratively speaking, shift its gears. During
wakefulness, the brain is geared fully toward processing information and behaving, while …

Mammals have two specialized vascular circulatory systems: the blood vasculature and the
lymphatic vasculature. The lymphatic vasculature is a unidirectional conduit that returns …

Disclosures: D. Máthé reported grants from European Union H2020 HCEMM-739593 and
from NRDIO, Hungary, TKP-BIOImaging-2020-4.1. 1-TKP2020 during the conduct of the …

Small vessel disease is a disorder of cerebral microvessels that causes white matter
hyperintensities and several other common abnormalities (eg, recent small subcortical …

Vascular contributions to cognitive impairment are increasingly recognized,,,–as shown by
neuropathological,, neuroimaging,,,–, and cerebrospinal fluid biomarker, studies. Moreover …

The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and
pathogens from entering the brain. At the same time, the BBB regulates transport of …

The blood-brain barrier (BBB) allows the brain to selectively import nutrients and energy
critical to neuronal function while simultaneously excluding neurotoxic substances from the …

The vast majority of the brain's vascular length is composed of capillaries, where our
understanding of blood flow control remains incomplete. This review synthesizes current …