Purpose To compare the clinical efficacy of high-dose prednisone monotherapy and the
combination of hormone and moderate-dose topiramate (TPM) therapy in children with …

Objective To describe the temporal trends in the cost and use of adrenocorticotropic
hormone (ACTH), oral prednisolone, and vigabatrin, the first‐line treatments for infantile …

Justification West syndrome is one of the commonest causes of epilepsy in infants and
young children and is a significant contributor to neurodevelopmental morbidity. Multiple …

(1) Background: West syndrome is a severe, refractory, epileptic syndrome that usually
appears in infancy or early childhood. ACTH is one of the more effective drugs for treating …

Objective: To compare the efficacy of oral dexamethasone and prednisolone in the treatment
of newly diagnosed children aged 3–36 months of West syndrome. Methods: An open …

Objectives: This study aims to compare the cost-effectiveness of oral prednisolone and
adrenocorticotropic hormone injection in West syndrome patients, the two most common …

There have been few case reports showing association of vitamin B12 deficiency with
infantile spasms. We planned this study to see if there was an association of serum vitamin …

Implementation of international guidelines for the treatment of epileptic spasms, is
challenging when access to adrenocorticotrophic hormone (ACTH) and vigabatrin is …

Infantile spasms, though long recognised, are still a cause of significant morbidity in
children. The knowledge of their etiology and pathogenesis is still evolving. Even the …

Background High dosages of natural adrenocorticotropic hormone are used in many centers
in the United States for the treatment of infantile spasms. However, lower dosages of …