Significance: Biomedical optics system design, image formation, and image analysis have
primarily been guided by classical physical modeling and signal processing methodologies …

Organoid models have been used to address important questions in developmental and
cancer biology, tissue repair, advanced modelling of disease and therapies, among other …

Fluorescence laser-scanning microscopy (LSM) is experiencing a revolution thanks to new
single-photon (SP) array detectors, which give access to an entirely new set of single-photon …

Significance: Fluorescence lifetime imaging microscopy (FLIM) measures the decay rate of
fluorophores, thus providing insights into molecular interactions. FLIM is a powerful …

Biomolecular condensates serve as membrane-less compartments within cells,
concentrating proteins and nucleic acids to facilitate precise spatial and temporal …

The removal of varnish from the surface is a key step in painting conservation. Varnish
removal is traditionally monitored by examining the painting surface under ultraviolet …

Measuring forces within living cells remains a technical challenge. We developed
hydrophobic mechanosensing fluorescent probes called Flippers, whose fluorescence …

In this paper, we develop a deep neural network based joint classification-regression
approach to identify microglia, a resident central nervous system macrophage, in the brain …

Fluorescence lifetime imaging microscopy (FLIM) has emerged as a promising tool for all
scientific studies in recent years. However, the utilization of FLIM data requires complex data …

Alzheimer's disease (AD) drives metabolic changes in the central nervous system (CNS). In
AD microglia are activated and proliferate in response to amyloid β plaques. To further …