Non-coding RNAs in lung cancer: molecular mechanisms and clinical applications

Y Liu, W Ding, J Wang, X Ao, J Xue - Frontiers in oncology, 2023 - frontiersin.org
Lung cancer (LC) is a heterogeneous disease with high malignant degree, rapid growth,
and early metastasis. The clinical outcomes of LC patients are generally poor due to the …

Unraveling therapeutic opportunities and the diagnostic potential of microRNAs for human lung cancer

O Sweef, E Zaabout, A Bakheet, M Halawa, I Gad… - Pharmaceutics, 2023 - mdpi.com
Lung cancer is a major public health problem and a leading cause of cancer-related deaths
worldwide. Despite advances in treatment options, the five-year survival rate for lung cancer …

Various LncRNA mechanisms in gene regulation involving miRNAs or RNA-binding proteins in non-small-cell lung cancer: main signaling pathways and networks

EA Braga, MV Fridman, AM Burdennyy… - International Journal of …, 2023 - mdpi.com
Long non-coding RNAs (lncRNAs) are crucial players in the pathogenesis of non-small-cell
lung cancer (NSCLC). A competing binding of lncRNAs and mRNAs with microRNAs …

Non-Coding RNAs as key regulators in lung cancer

I Gilyazova, G Gimalova, A Nizamova… - International journal of …, 2023 - mdpi.com
For several decades, most lung cancer investigations have focused on the search for
mutations in candidate genes; however, in the last decade, due to the fact that most of the …

[HTML][HTML] The bidirectional interplay between ncRNAs and methylation modifications in gastrointestinal tumors

M Kong, X Yu, W Guo, R Guo - International Journal of Biological …, 2023 - ncbi.nlm.nih.gov
The aberrant expression of methylation and ncRNAs, two crucial regulators of epigenetic
modifications, has been widely demonstrated in cancer. The complex interplay between …

MicroRNAs and the Mediterranean diet: a nutri-omics perspective for lung cancer

R Cuttano, F Mazzarelli, KM Afanga, F Bianchi… - Journal of translational …, 2024 - Springer
Lung cancer is the deadliest cancer type worldwide with~ 1.8 million deaths per-year.
Smoking accounts for~ 85% of all cases, with a described joint effect with unhealthy diet in …

[HTML][HTML] Abnormal expressions of PURPL, miR-363-3p and ADAM10 predicted poor prognosis for patients with ovarian serous cystadenocarcinoma

R Zhang, X Guo, L Zhao, T He, W Feng, S Ren - Journal of Cancer, 2023 - ncbi.nlm.nih.gov
Objective: This study aimed to elucidate the prognostic implications of deviant expressions
of long non-coding RNA (lncRNA) p53 upregulated regulator of p53 levels (PURPL) …

circ_PPAPDC1A promotes Osimertinib resistance by sponging the miR-30a-3p/IGF1R pathway in non-small cell lung cancer (NSCLC)

Y Tang, Z Liu, L Zhang, S Shi, S Xu, JA Ma, CH Hu… - Molecular Cancer, 2024 - Springer
Background Recent evidence has demonstrated that abnormal expression and regulation of
circular RNA (circRNAs) are involved in the occurrence and development of a variety of …

ADAMTS gene-derived circRNA molecules in non-small-cell lung cancer: expression profiling, clinical correlations and survival analysis

J Pietrzak, R Świechowski, A Wosiak, S Wcisło… - International Journal of …, 2024 - mdpi.com
The present study examines the relationship between circular RNA (circRNA) derived from
three genes of the family a disintegrin and metalloproteinase with thrombospondin motifs …

Vitamin D-mediated tsRNA-07804 triggers mitochondrial dysfunction and suppresses non-small cell lung cancer progression by targeting CRKL

Y Liang, X Zhang, J Peng, J Liu, H Chen… - Journal of Cancer …, 2024 - Springer
Objective tRNA-derived small RNAs (tsRNAs) are novel non-coding RNAs with various
functions in multiple cancers. Nevertheless, whether vitamin D executes its function in …