Metabolic regulation of endothelial senescence
NT Le - Frontiers in Cardiovascular Medicine, 2023 - frontiersin.org
Endothelial cell (EC) senescence is increasingly recognized as a significant contributor to
the development of vascular dysfunction and age-related disorders and diseases, including …
the development of vascular dysfunction and age-related disorders and diseases, including …
Concentration fluctuations in growing and dividing cells: Insights into the emergence of concentration homeostasis
Intracellular reaction rates depend on concentrations and hence their levels are often
regulated. However classical models of stochastic gene expression lack a cell size …
regulated. However classical models of stochastic gene expression lack a cell size …
Coupling gene expression dynamics to cell size dynamics and cell cycle events: Exact and approximate solutions of the extended telegraph model
The standard model describing the fluctuations of mRNA numbers in single cells is the
telegraph model which includes synthesis and degradation of mRNA, and switching of the …
telegraph model which includes synthesis and degradation of mRNA, and switching of the …
Frequency domain analysis of fluctuations of mRNA and protein copy numbers within a cell lineage: theory and experimental validation
The stochasticity of gene expression is manifested in the fluctuations of messenger
ribonucleic acid and protein copy numbers within a cell lineage over time. While data of this …
ribonucleic acid and protein copy numbers within a cell lineage over time. While data of this …
Analytical time-dependent distributions for gene expression models with complex promoter switching mechanisms
Classical gene expression models assume exponential switching time distributions between
the active and inactive promoter states. However, recent experiments have shown that many …
the active and inactive promoter states. However, recent experiments have shown that many …
Poisson representation: a bridge between discrete and continuous models of stochastic gene regulatory networks
Stochastic gene expression dynamics can be modelled either discretely or continuously.
Previous studies have shown that the mRNA or protein number distributions of some simple …
Previous studies have shown that the mRNA or protein number distributions of some simple …
Mechanisms of cell size regulation in slow-growing Escherichia coli cells: discriminating models beyond the adder
Under ideal conditions, Escherichia coli cells divide after adding a fixed cell size, a strategy
known as the adder. This concept applies to various microbes and is often explained as the …
known as the adder. This concept applies to various microbes and is often explained as the …
Quantitative Examination of Five Stochastic Cell-Cycle and Cell-Size Control Models for Escherichia coli and Bacillus subtilis
We examine five quantitative models of the cell-cycle and cell-size control in Escherichia coli
and Bacillus subtilis that have been proposed over the last decade to explain single-cell …
and Bacillus subtilis that have been proposed over the last decade to explain single-cell …
Mitochondrial network structure controls cell-to-cell mtDNA variability generated by cell divisions
RC Glastad, IG Johnston - PLOS Computational Biology, 2023 - journals.plos.org
Mitochondria are highly dynamic organelles, containing vital populations of mitochondrial
DNA (mtDNA) distributed throughout the cell. Mitochondria form diverse physical structures …
DNA (mtDNA) distributed throughout the cell. Mitochondria form diverse physical structures …
Analytical cell size distribution: lineage-population bias and parameter inference
A Genthon - Journal of the Royal Society Interface, 2022 - royalsocietypublishing.org
We derive analytical steady-state cell size distributions for size-controlled cells in single-
lineage experiments, such as the mother machine, which are fundamentally different from …
lineage experiments, such as the mother machine, which are fundamentally different from …