[HTML][HTML] Coupling cell size regulation and proliferation dynamics of C. glutamicum reveals cell division based on surface area

C Nieto, S Täuber, L Blöbaum, Z Vahdat, A Grünberger… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Single cells actively coordinate growth and division to regulate their size, yet how this size
homeostasis at the single-cell level propagates over multiple generations to impact clonal …

The role of division stochasticity on the robustness of bacterial size dynamics

C Nieto, JC Arias-Castro, C Sánchez, C Vargas-García… - bioRxiv, 2022 - biorxiv.org
Variables of bacterial division such as size at birth, growth rate, division time, and the
position of the septal ring, all vary from cell to cell. Currently, it is unknown how these …

Equivalence framework for an age-structured multistage representation of the cell cycle

JC Kynaston, C Guiver, CA Yates - Physical Review E, 2022 - APS
We develop theoretical equivalences between stochastic and deterministic models for
populations of individual cells stratified by age. Specifically, we develop a hierarchical …

Cell size regulation and proliferation fluctuations in single-cell derived colonies

C Nieto, C Vargas-García, JM Pedraza, A Singh - bioRxiv, 2022 - biorxiv.org
Exponentially growing cells regulate their size by controlling their timing of division. Since
two daughter cells are born as a result of this cell splitting, cell size regulation has a direct …

[PDF][PDF] Statistical properties of dynamical models underlying cell size homeostasis

C Nieto, CA Vargas-Garcia, A Singh - tech. rep., Center for Open Science, 2023 - osf.io
In this contribution, we use the framework of discrete-event dynamical systems to model a
fundamental aspect of lifethe proliferation of cells. This process starts with a newborn cell …

Continuous Approximation of Stochastic Maps for Modeling Asymmetric Cell Division

A Arcobi, S Burov - arXiv preprint arXiv:2307.09391, 2023 - arxiv.org
Cell size control and homeostasis is a major topic in cell biology yet to be fully understood.
Several growth laws like the timer, adder, and sizer were proposed, and mathematical …

A Moments-Based Analytical Approach for Cell Size Homeostasis

C Nieto, CA Vargas-Garcia… - IEEE Control Systems …, 2024 - ieeexplore.ieee.org
This contribution explores mechanisms that regulate the dynamics of single-cell size,
maintaining equilibrium around a target set point. Using the formalism of Stochastic Hybrid …

Master equation approach to the stochastic accumulation dynamics of bacterial cell cycle

L Luo, Y Bai, X Fu - New Journal of Physics, 2021 - iopscience.iop.org
The mechanism of bacterial cell size control has been a mystery for decades, which involves
the well-coordinated growth and division in the cell cycle. The revolutionary modern …

Cell-division time statistics from stochastic exponential threshold-crossing

K Biswas, N Brenner - BioRxiv, 2022 - biorxiv.org
For cell division to take place, proteins that carry it out need to accumulate to a functional
threshold. Most of these divisome proteins are highly abundant in the cell, and accumulate …

Competition between transient oscillations and early stochasticity in exponentially growing populations

Y Hein, F Jafarpour - arXiv preprint arXiv:2310.20011, 2023 - arxiv.org
It has been recently shown that the exponential growth rate of a population of bacterial cells
starting from a single cell will show transient oscillations due to early synchronized bursts of …