Cancer is a global health challenge that remains to be a field of extensive research aiming
to find new anticancer therapeutics. The 20S proteasome complex is one of the targets of …

Objectives To investigate the synergistic mechanisms of Paris Saponin II (PSII) and
Curcumin (CUR) in lung cancer. Materials and Methods The combination changed the …

Pharmacological perturbation studies based on protein-level signatures are fundamental for
drug discovery. In the present study, we used a mass spectrometry (MS)-based proteomic …

Several pathways are deregulated during carcinogenesis but most notably, tumour cells can
lose cell cycle control and acquire resistance to apoptosis by expressing a number of anti …

Invasive breast cancer is the most common type of malignancy in women worldwide.
However, the mechanism responsible for breast cancer metastasis is still unclear and needs …

Cisplatin is one of the most common drugs used for treatment of solid tumors such as
ovarian cancer. Unfortunately, the development of resistance against this cytotoxic agent …

Gastric cancer is one of the most common malignant tumors worldwide; however, the
efficacy of clinical treatment is limited. MicroRNAs (miRNAs) are a class of small non-coding …

BACKGROUND: The expression of a gene is a process that conveys information of genes to
synthesise gene product is functional. Alterations of the molecular biology in breast cancer …

Proteasome inhibition interfering with many cell signaling pathways has been extensively
explored as a therapeutic strategy for cancers. Proteasome inhibitor YSY01A is a novel …

It is believed that the alteration of tissue microenvironment would affect cancer initiation and
progression. However, little is known in terms of the underlying molecular mechanisms that …