[PDF][PDF] Inflammation in obesity, diabetes, and related disorders
Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …
[HTML][HTML] The effect of HIF on metabolism and immunity
Cellular hypoxia occurs when the demand for sufficient molecular oxygen needed to
produce the levels of ATP required to perform physiological functions exceeds the vascular …
produce the levels of ATP required to perform physiological functions exceeds the vascular …
Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …
A new perspective on NAFLD: Focusing on lipid droplets
E Scorletti, RM Carr - Journal of hepatology, 2022 - Elsevier
Lipid droplets (LDs) are complex and metabolically active organelles. They are composed of
a neutral lipid core surrounded by a monolayer of phospholipids and proteins. LD …
a neutral lipid core surrounded by a monolayer of phospholipids and proteins. LD …
Kidney physiology and susceptibility to acute kidney injury: implications for renoprotection
H Scholz, FJ Boivin, KM Schmidt-Ott… - Nature Reviews …, 2021 - nature.com
Kidney damage varies according to the primary insult. Different aetiologies of acute kidney
injury (AKI), including kidney ischaemia, exposure to nephrotoxins, dehydration or sepsis …
injury (AKI), including kidney ischaemia, exposure to nephrotoxins, dehydration or sepsis …
Chronic tissue inflammation and metabolic disease
YS Lee, J Olefsky - Genes & development, 2021 - genesdev.cshlp.org
Obesity is the most common cause of insulin resistance, and the current obesity epidemic is
driving a parallel rise in the incidence of T2DM. It is now widely recognized that chronic …
driving a parallel rise in the incidence of T2DM. It is now widely recognized that chronic …
[HTML][HTML] Multimodal single cell sequencing implicates chromatin accessibility and genetic background in diabetic kidney disease progression
The proximal tubule is a key regulator of kidney function and glucose metabolism. Diabetic
kidney disease leads to proximal tubule injury and changes in chromatin accessibility that …
kidney disease leads to proximal tubule injury and changes in chromatin accessibility that …
[HTML][HTML] Controversies in optimal anemia management: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference
In chronic kidney disease, anemia and disordered iron homeostasis are prevalent and
associated with significant adverse consequences. In 2012, Kidney Disease: Improving …
associated with significant adverse consequences. In 2012, Kidney Disease: Improving …
Medical conditions and high-altitude travel
AM Luks, PH Hackett - New England Journal of Medicine, 2022 - Mass Medical Soc
High-Altitude Travel with Medical Problems Travel to high altitude is increasing. The authors
discuss physiological changes at high altitude, pretravel evaluation for common medical …
discuss physiological changes at high altitude, pretravel evaluation for common medical …
[HTML][HTML] Safety and efficacy of vadadustat for anemia in patients undergoing dialysis
KU Eckardt, R Agarwal, A Aswad, A Awad… - … England Journal of …, 2021 - Mass Medical Soc
Background Vadadustat is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor, a
class of compounds that stimulate endogenous erythropoietin production. Methods We …
class of compounds that stimulate endogenous erythropoietin production. Methods We …