Autoimmune diseases (AID) are increasingly prevalent conditions which comprise more
than 100 distinct clinical entities that are responsible for a great disease burden worldwide …

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease affecting joints and
causing progressive damage and disability. Macrophages are of critical importance in the …

Patients with rheumatoid arthritis (RA) receive highly targeted biologic therapies without
previous knowledge of target expression levels in the diseased tissue. Approximately 40 …

Background Although targeted biological treatments have transformed the outlook for
patients with rheumatoid arthritis, 40% of patients show poor clinical response, which is …

Rheumatoid arthritis (RA) is an inflammatory disease that begins with a loss of tolerance to
modified self-antigens and immune system abnormalities, eventually leading to synovitis …

Lymph node stromal cells coordinate the adaptive immune response in secondary lymphoid
organs, providing both a structural matrix and soluble factors that regulate survival and …

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterised by local and
systemic inflammation where the close interaction between immune cells and soluble …

Single-cell RNA sequencing (scRNA-seq) technology can analyze the transcriptome
expression level of cells with high-throughput from the single cell level, fully show the …

Memory B cells (MBCs) are an essential part of our immunological memory. They respond
fast upon re-encountering pathogens and can differentiate into plasma cells that secrete …

Background Despite highly effective targeted therapies for rheumatoid arthritis, about 40% of
patients respond poorly, and predictive biomarkers for treatment choices are lacking. We did …