[HTML][HTML] Metabolism of the endocannabinoid anandamide: open questions after 25 years
M Maccarrone - Frontiers in molecular neuroscience, 2017 - frontiersin.org
Cannabis extracts have been used for centuries, but its main active principle∆ 9-
tetrahydrocannabinol (THC) was identified about 50 years ago. Yet, it is only 25 years ago …
tetrahydrocannabinol (THC) was identified about 50 years ago. Yet, it is only 25 years ago …
Enhanced endocannabinoid tone as a potential target of pharmacotherapy
M Toczek, B Malinowska - Life sciences, 2018 - Elsevier
The endocannabinoid system is up-regulated in numerous pathophysiological states such
as inflammatory, neurodegenerative, gastrointestinal, metabolic and cardiovascular …
as inflammatory, neurodegenerative, gastrointestinal, metabolic and cardiovascular …
Targeting endocannabinoid signaling: FAAH and MAG lipase inhibitors
N van Egmond, VM Straub… - Annual Review of …, 2021 - annualreviews.org
Inspired by the medicinal properties of the plant Cannabis sativa and its principal
component (−)-trans-Δ9-tetrahydrocannabinol (THC), researchers have developed a variety …
component (−)-trans-Δ9-tetrahydrocannabinol (THC), researchers have developed a variety …
Monoglyceride lipase as a drug target: At the crossroads of arachidonic acid metabolism and endocannabinoid signaling
GF Grabner, R Zimmermann, R Schicho… - Pharmacology & …, 2017 - Elsevier
Monoglyerides (MGs) are short-lived, intermediary lipids deriving from the degradation of
phospho-and neutral lipids, and monoglyceride lipase (MGL), also designated as …
phospho-and neutral lipids, and monoglyceride lipase (MGL), also designated as …
The endocannabinoidome in neuropsychiatry: Opportunities and potential risks
G Morris, K Walder, S Kloiber, P Amminger… - Pharmacological …, 2021 - Elsevier
The endocannabinoid system (ECS) comprises two cognate endocannabinoid receptors
referred to as CB1R and CB2R. ECS dysregulation is apparent in neurodegenerative/neuro …
referred to as CB1R and CB2R. ECS dysregulation is apparent in neurodegenerative/neuro …
Mechanisms of endocannabinoid control of synaptic plasticity
BL Winters, CW Vaughan - Neuropharmacology, 2021 - Elsevier
The endogenous cannabinoid transmitter system regulates synaptic transmission
throughout the nervous system. Unlike conventional transmitters, specific stimuli induce …
throughout the nervous system. Unlike conventional transmitters, specific stimuli induce …
Immunoregulatory role of cannabinoids during infectious disease
R Hernández-Cervantes, M Méndez-Díaz… - …, 2018 - karger.com
Although the endocannabinoid system (ECS) is involved in the regulation of several
physiological processes, including sleep and the immune response, its role during infections …
physiological processes, including sleep and the immune response, its role during infections …
Interaction between cannabinoid system and toll‐like receptors controls inflammation
KL McCoy - Mediators of inflammation, 2016 - Wiley Online Library
Since the discovery of the endocannabinoid system consisting of cannabinoid receptors,
endogenous ligands, and biosynthetic and metabolizing enzymes, interest has been …
endogenous ligands, and biosynthetic and metabolizing enzymes, interest has been …
[HTML][HTML] “The Two Sides of the Same Coin”—Medical Cannabis, Cannabinoids and Immunity: Pros and Cons Explained
M Khoury, I Cohen, G Bar-Sela - Pharmaceutics, 2022 - mdpi.com
Cannabis, as a natural medicinal remedy, has long been used for palliative treatment to
alleviate the side effects caused by diseases. Cannabis-based products isolated from plant …
alleviate the side effects caused by diseases. Cannabis-based products isolated from plant …
[HTML][HTML] Recent advances in endocannabinoid system targeting for improved specificity: strategic approaches to targeted drug delivery
Opportunities for developing innovative and intelligent drug delivery technologies by
targeting the endocannabinoid system are becoming more apparent. This review provides …
targeting the endocannabinoid system are becoming more apparent. This review provides …