Harnessing 3D in vitro systems to model immune responses to solid tumours: a step towards improving and creating personalized immunotherapies
In vitro 3D models are advanced biological tools that have been established to overcome
the shortcomings of oversimplified 2D cultures and mouse models. Various in vitro 3D …
the shortcomings of oversimplified 2D cultures and mouse models. Various in vitro 3D …
Immunotherapy discovery on tumor organoid-on-a-chip platforms that recapitulate the tumor microenvironment
Cancer immunotherapy has achieved remarkable success over the past decade by
modulating patients' own immune systems and unleashing pre-existing immunity. However …
modulating patients' own immune systems and unleashing pre-existing immunity. However …
Cuproptosis correlates with immunosuppressive tumor microenvironment based on pan-cancer multiomics and single-cell sequencing analysis
Y Qin, Y Liu, X Xiang, X Long, Z Chen, X Huang… - Molecular cancer, 2023 - Springer
Recent studies suggest that cuproptosis, a novel mode of cell death, may be associated with
the development of cancer. However, no studies are showing its role in tumorigenesis …
the development of cancer. However, no studies are showing its role in tumorigenesis …
Nanomaterials: small particles show huge possibilities for cancer immunotherapy
Z Chen, Z Yue, K Yang, S Li - Journal of Nanobiotechnology, 2022 - Springer
With the economy's globalization and the population's aging, cancer has become the
leading cause of death in most countries. While imposing a considerable burden on society …
leading cause of death in most countries. While imposing a considerable burden on society …
Recent advances of organ-on-a-chip in cancer modeling research
X Liu, Q Su, X Zhang, W Yang, J Ning, K Jia, J Xin, H Li… - Biosensors, 2022 - mdpi.com
Although many studies have focused on oncology and therapeutics in cancer, cancer
remains one of the leading causes of death worldwide. Due to the unclear molecular …
remains one of the leading causes of death worldwide. Due to the unclear molecular …
Microporogen‐Structured Collagen Matrices for Embedded Bioprinting of Tumor Models for Immuno‐Oncology
Embedded bioprinting enables the rapid design and fabrication of complex tissues that
recapitulate in vivo microenvironments. However, few biological matrices enable good print …
recapitulate in vivo microenvironments. However, few biological matrices enable good print …
Insights into the Tumor Microenvironment—Components, Functions and Therapeutics
Similarly to our healthy organs, the tumor tissue also constitutes an ecosystem. This implies
that stromal cells acquire an altered phenotype in tandem with tumor cells, thereby …
that stromal cells acquire an altered phenotype in tandem with tumor cells, thereby …
A multi-organ-on-chip to recapitulate the infiltration and the cytotoxic activity of circulating NK cells in 3D matrix-based tumor model
The success of immunotherapeutic approaches strictly depends on the immune cells
interaction with cancer cells. While conventional in vitro cell cultures under-represent the …
interaction with cancer cells. While conventional in vitro cell cultures under-represent the …
Translation of cell therapies to treat autoimmune disorders
Autoimmune diseases are a diverse and complex set of chronic disorders with a substantial
impact on patient quality of life and a significant global healthcare burden. Current …
impact on patient quality of life and a significant global healthcare burden. Current …
Targeting lipid metabolism reprogramming of immunocytes in response to the tumor microenvironment stressor: A potential approach for tumor therapy
M Zhang, T Wei, X Zhang, D Guo - Frontiers in Immunology, 2022 - frontiersin.org
The tumor microenvironment (TME) has become a major research focus in recent years. The
TME differs from the normal extracellular environment in parameters such as nutrient supply …
TME differs from the normal extracellular environment in parameters such as nutrient supply …