The prevalence of metabolic diseases, including obesity, dyslipidemia, type 2 diabetes
mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD), is a severe burden in human …

A long-term complication of obesity is the development of type 2 diabetes (T2D). Patients
with T2D have been described as having epigenetic modifications. Epigenetics is the post …

Bone metabolism consists of a balance between bone formation and bone resorption, which
is mediated by osteoblast and osteoclast activity, respectively. In order to ensure bone …

Pancreatic β cell expansion and functional maturation during the birth-to-weaning period is
driven by epigenetic programs primarily triggered by growth factors, hormones, and nutrients …

DNA methylation controls DNA accessibility to transcription factors and other regulatory
proteins, thereby affecting gene expression and hence cellular identity and function. As …

The ability to maintain normoglycaemia, through glucose-sensitive insulin release, is a key
aspect of postnatal beta cell function. However, terminally differentiated beta cell identity …

Simple Summary Epigenetics is a somatic, heritable pattern of gene expression or cellular
phenotype mediated by structural changes in chromatin that occur without altering the DNA …

Abstract Development of the human pancreas requires the precise temporal control of gene
expression via epigenetic mechanisms and the binding of key transcription factors. We …

Epigenetic regulation, mainly involving DNA methylation, histone modification, and
noncoding RNAs (ncRNAs), is essential for the regulation of multiple cellular processes …

Cholestenoic acid (CA) has been reported as an important biomarker of many severe
diseases, but its physiological and pathological roles remain unclear. This study aimed to …