The discovery of Notch in Drosophila melanogaster nearly a century ago opened the door to
an ever-widening understanding of cellular processes that are controlled or influenced by …

Notch signaling regulates many aspects of metazoan development and tissue renewal.
Accordingly, the misregulation or loss of Notch signaling underlies a wide range of human …

Notch signaling controls numerous cell-fate specification events in multicellular organisms,
and dysregulated Notch signaling causes several diseases with underlying developmental …

Prmt5, an arginine methyltransferase, has multiple roles in germ cells, and possibly in
pluripotency. Here we show that loss of Prmt5 function is early embryonic-lethal due to the …

Notch proteins are the receptors in a highly conserved signal transduction system used to
communicate signals between cells that contact each other. Studies investigating structure …

Adult stem cells maintain tissue homeostasis by controlling the proper balance of stem cell
self-renewal and differentiation. The adult midgut of Drosophila contains multipotent …

The Notch signaling pathway is a highly conserved developmental pathway, which plays a
critical role in cell-fate decision, tissue patterning and morphogenesis. There is increasing …

Mammalian cells possess two isoforms of the histone H3–H4 chaperone anti‐silencing
function 1 (Asf1), Asf1a and Asf1b. However to date, whether they have individual …

The proteolytic cleavages elicited by activation of the Notch receptor release an intracellular
fragment, Notch intracellular domain, which enters the nucleus to activate the transcription of …

Histone chaperones are involved in a variety of chromatin transactions. By a proteomics
survey, we identified the interaction networks of histone chaperones ASF1, CAF1, HIRA, and …