Untargeted metabolomics, as a global approach, has already proven its great potential and
capabilities for the investigation of health and disease, as well as the wide applicability for …

The life sciences are currently being transformed by an unprecedented wave of
developments in molecular analysis, which include important advances in instrumental …

Human blood is a self-regenerating lipid-rich biological fluid that is routinely collected in
hospital settings. The inventory of lipid molecules found in blood plasma (plasma lipidome) …

Objective Current non-invasive diagnostic tests can distinguish between pancreatic cancer
(pancreatic ductal adenocarcinoma (PDAC)) and chronic pancreatitis (CP) in only about two …

Metabolomics refers to the large-scale detection, quantification, and analysis of small
molecules (metabolites) in biological media. Although metabolomics, alone or combined …

Every day, analytical and bio-analytical chemists make sustained efforts to improve the
sensitivity, specificity, robustness, and reproducibility of their methods. Especially in targeted …

Blood derivatives are the biofluids of choice for metabolomic clinical studies since blood can
be collected with low invasiveness and is rich in biological information. However, the choice …

Metabolomics provides a comprehensive assessment of numerous small molecules in
biological samples. As it integrates the effects of exogenous exposures, endogenous …

Metabolomics can be significantly influenced by a range of pre-analytical factors, such as
sample collection, pre-processing, aliquoting, transport, storage and thawing. This therefore …

The exposome, defined as the cumulative measure of external exposures and associated
biological responses throughout the lifespan, has emerged in recent years as a cornerstone …