Systemic autoinflammatory diseases (SAIDs) are a growing group of disorders caused by a
dysregulation of the innate immune system leading to episodes of systemic inflammation. In …

Neutrophil granulocytes, or neutrophils, are the most abundant circulating leukocytes in
humans and indispensable for antimicrobial immunity, as exemplified in patients with inborn …

Autoinflammatory disorders and autoimmune diseases result from abnormal deviations of
innate and adaptive immunity that heterogeneously affect organs and clinical phenotypes …

In this review we give an overview of the NAIP/NLRC4 activation mechanism as well as the
described roles of this inflammasome, with a focus on in vivo infection and pathology. After …

Systemic autoinflammatory diseases (SAIDs) are a group of monogenic diseases
characterized by disordered innate immunity, which causes excessive activation of …

A dysregulated immune response toward self-antigens characterizes autoimmune and
autoinflammatory (AIF) disorders. Autoantibodies or autoreactive T cells contribute to …

Dysregulation of innate immune responses can result in chronic inflammatory conditions.
Glucocorticoids, the current frontline therapy, are effective immunosuppressive drugs but …

Background Autoimmunity is used to cause by impairment of adaptive immunity alone,
whereas autoinflammatory was originally defined as a consequence of unregulated innate …

Mutations in nucleotide-binding oligomerization domain-containing protein 2 (NOD2) cause
Blau syndrome, an inflammatory disorder characterized by uveitis. The antimicrobial …

A growing body of evidence suggests that postural orthostatic tachycardia syndrome (POTS)
may be an autoimmune disorder. We have reported in a previous manuscript that 89% of …