Neurohormonal changes in the gut–brain axis and underlying neuroendocrine mechanisms following bariatric surgery

E Martinou, I Stefanova, E Iosif, AM Angelidi - International journal of …, 2022 - mdpi.com
Obesity is a complex, multifactorial disease that is a major public health issue worldwide.
Currently approved anti-obesity medications and lifestyle interventions lack the efficacy and …

[HTML][HTML] Hungry for relief: Potential for neurotensin to address comorbid obesity and pain

R Khan, G Laumet, GM Leinninger - Appetite, 2024 - Elsevier
Chronic pain and obesity frequently occur together. An ideal therapy would alleviate pain
without weight gain, and most optimally, could promote weight loss. The neuropeptide …

Expression of neurotensin and its receptors along the intestinal tract in type 2 diabetes patients and healthy controls

H Gilliam-Vigh, T Jorsal, SW Nielsen… - The Journal of …, 2023 - academic.oup.com
Context Enteroendocrine N cells secrete neurotensin (NTS). NTS reduces food intake in
rodents and may increase insulin release. In humans, postprandial NTS responses increase …

The effects of Calorie restriction and Bariatric surgery on Circulating Proneurotensin levels

MG Miskelly, J Berggren, M Svensson… - The Journal of …, 2024 - academic.oup.com
Context Proneurotensin (pNT) is associated with obesity and type 2 diabetes (T2D), but the
effects of Roux-en-Y gastric bypass (RYGB) on postprandial pNT levels are not well studied …

New Lessons from the gut: studies of the role of gut peptides in weight loss and diabetes resolution after gastric bypass and sleeve gastrectomy

JJ Holst, S Madsbad, KN Bojsen-Møller, C Dirksen… - Peptides, 2024 - Elsevier
It has been known since 2005 that the secretion of several gut hormones changes radically
after gastric bypass operations and, although more moderately, after sleeve gastrectomy but …