Associations between female sex, sarcomere variants, and clinical outcomes in hypertrophic cardiomyopathy
Background: The impact of sex on phenotypic expression in hypertrophic cardiomyopathy
(HCM) has not been well characterized in genotyped cohorts. Methods: Retrospective cohort …
(HCM) has not been well characterized in genotyped cohorts. Methods: Retrospective cohort …
Cardiac myosin inhibitors as a novel treatment option for obstructive hypertrophic cardiomyopathy: addressing the core of the matter
A Masri, I Olivotto - Journal of the American Heart Association, 2022 - Am Heart Assoc
The modern perception of hypertrophic cardio-myopathy (HCM), matured over the past 6
decades, is that of a common, genetically diverse, multi-faceted disease. The meticulous …
decades, is that of a common, genetically diverse, multi-faceted disease. The meticulous …
Establishment of specialized clinical cardiovascular genetics programs: recognizing the need and meeting standards: a scientific statement from the American Heart …
F Ahmad, EM McNally, MJ Ackerman… - Circulation: Genomic …, 2019 - Am Heart Assoc
Cardiovascular genetics is a rapidly evolving subspecialty within cardiovascular medicine,
and its growth is attributed to advances in genome sequencing and genetic testing and the …
and its growth is attributed to advances in genome sequencing and genetic testing and the …
[HTML][HTML] Effects of MYBPC3 loss-of-function mutations preceding hypertrophic cardiomyopathy
AS Helms, VT Tang, TS O'Leary, S Friedline… - JCI insight, 2020 - ncbi.nlm.nih.gov
Mutations in cardiac myosin binding protein C (MyBP-C, encoded by MYBPC3) are the most
common cause of hypertrophic cardiomyopathy (HCM). Most MYBPC3 mutations result in …
common cause of hypertrophic cardiomyopathy (HCM). Most MYBPC3 mutations result in …
Sex differences in hypertrophic cardiomyopathy: interaction with genetics and environment
Abstract Purpose of Review We explore the sex-specific interaction of genetics and the
environment on the clinical course and outcomes of hypertrophic cardiomyopathy (HCM) …
environment on the clinical course and outcomes of hypertrophic cardiomyopathy (HCM) …
External validation of the HCM Risk-Kids model for predicting sudden cardiac death in childhood hypertrophic cardiomyopathy
Aims Sudden cardiac death (SCD) is the most common mode of death in childhood
hypertrophic cardiomyopathy (HCM). The newly developed HCM Risk-Kids model provides …
hypertrophic cardiomyopathy (HCM). The newly developed HCM Risk-Kids model provides …
Temporal trend of age at diagnosis in hypertrophic cardiomyopathy: an analysis of the international sarcomeric human cardiomyopathy registry
M Canepa, C Fumagalli, G Tini… - Circulation: Heart …, 2020 - Am Heart Assoc
Background: Over the last 50 years, the epidemiology of hypertrophic cardiomyopathy
(HCM) has changed because of increased awareness and availability of advanced …
(HCM) has changed because of increased awareness and availability of advanced …
Mortality among referral patients with hypertrophic cardiomyopathy vs the general European population
M Lorenzini, Z Anastasiou, C O'Mahony… - JAMA …, 2020 - jamanetwork.com
Importance It is unclear whether hypertrophic cardiomyopathy (HCM) conveys excess
mortality when compared with the general population. Objective To compare the survival of …
mortality when compared with the general population. Objective To compare the survival of …
Contemporary insights into the genetics of hypertrophic cardiomyopathy: toward a new era in clinical testing?
F Mazzarotto, I Olivotto, B Boschi… - Journal of the …, 2020 - Am Heart Assoc
Genetic testing for hypertrophic cardiomyopathy (HCM) is an established clinical technique,
supported by 30 years of research into its genetic etiology. Although pathogenic variants are …
supported by 30 years of research into its genetic etiology. Although pathogenic variants are …
Study design and rationale of EXPLORER-HCM: evaluation of mavacamten in adults with symptomatic obstructive hypertrophic cardiomyopathy
Background: Obstructive hypertrophic cardiomyopathy (oHCM) is characterized by
unexplained left ventricular (LV) hypertrophy associated with dynamic LV outflow tract …
unexplained left ventricular (LV) hypertrophy associated with dynamic LV outflow tract …